Systemic Delivery of Small Interfering RNA by Use of Targeted Polycation Liposomes for Cancer Therapy
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概要
- 論文の詳細を見る
Novel polycation liposomes decorated with cyclic(Cys-Arg-Gly-Asp-D-Phe) peptide (cyclicRGD)-polyethylene glycol (PEG) (RGD-PEG-polycation liposomes (PCL)) were previously developed for cancer therapy based on RNA interference. Here, we demonstrate the in vivo delivery of small interfering RNA (siRNA) to tumors by use of RGD-PEG-PCL in B16F10 melanoma-bearing mice. Pharmacokinetic data obtained by positron emission tomography showed that cholesterol-conjugated siRNA formulated in RGD-PEG-PCL markedly accumulated in the tumors. Delivered by RGD-PEG-PCL, a therapeutic cocktail of siRNAs composed of cholesterol-conjugated siRNAs for c-myc, MDM2, and vascular endothelial growth factor (VEGF) were able to significantly inhibit the growth of B16F10 melanoma both in vitro and in vivo. These data suggest that targeted delivery of siRNAs by use of RGD-PEG-PCL has considerable potential for cancer treatment.
著者
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Asai Tomohiro
Department Of Cardiovascular Surgery Okayama University Graduate School Of Medicine Dentistry And Ph
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Nango Mamoru
Department Of Applied Chemistry Fculty Of Engineering Nagoya Insitute Of Technology
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SHIMIZU Kosuke
Department of Medical Biochemistry and COE Program in the 21st Century, School of Pharmaceutical Sci
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Tsukada Hideo
Pet Center Central Research Laboratory
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Hatanaka Kentaro
Department Of Medical Biochemistry And Global Coe University Of Shizuoka School Of Pharmaceutical Sc
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Urita Yugo
Department Of Frontier Materials Graduate School Of Engineering Nagoya Institute Of Technology
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DEWA Takehisa
Department of Applied Chemistry, Nagoya Institute of Technology
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OKU Naoto
Department of Biochemistry, Faculty of Pharmaceutical Sciences, Setsunan University
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Tsukada Hideo
PET Center, Central Research Laboratory, Hamamatsu Photonics K.K.
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Ishii Takayuki
Department of Applied Chemistry, Faculty of Engineering, Kanagawa University
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Kenjo Eriya
Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka
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Yonenaga Norihito
Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka
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Ando Hidenori
Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka
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