Nanoparticle-Mediated Delivery of Anticancer Agents to Tumor Angiogenic Vessels
スポンサーリンク
概要
- 論文の詳細を見る
Nanoparticle-mediated drug delivery systems targeting tumor angiogenic vessels have been studied for antineovascular cancer therapy achieved by induction of apoptosis of angiogenic endothelial cells. Nanoparticles such as liposomes are considered to accumulate in tumors due to the enhanced permeability and retention effect. The delivery efficiency of this system appears to be affected by the density of tumor angiogenic vessels regardless of modification with tumor-targeting ligands on the surface of nanoparticles. It remains a challenging problem to deliver sufficient amounts of anticancer drugs to hypovascular tumors using nanoparticles. On the other hand, the strategy of angiogenic vessel-targeting is theoretically different from that of tumor cell-targeting since target angiogenic endothelial cells face the circulating blood. In addition, this strategy is expected to cause indirect tumor regression by disrupting angiogenic vessels. In this review, our recent studies are summarized to show the actual efficacy of angiogenic vessel-targeting delivery. We have developed various angiogenic vessel-targeted liposomes and evaluated them in experimental cancer models such as drug-resistant and hypovascular tumors. Our data indicate that increased apoptosis of angiogenic endothelial cells can be achieved by the targeted liposomes encapsulating cytotoxic drugs, resulting in enhanced anticancer effects. The advantages of angiogenic vessel-targeting are discussed based on our recent findings to provide an insight into why angiogenic vessels are a promising target for advanced cancer therapy.
著者
-
Asai Tomohiro
Department Of Cardiovascular Surgery Okayama University Graduate School Of Medicine Dentistry And Ph
-
Asai Tomohiro
Department of Medical Biochemistry, Graduate Division of Pharmaceutical Sciences, University of Shizuoka
関連論文
- Preventive Effect of Green Tea Catechins on Experimental Tumor Metastasis in Senescence-Accelerated Mice
- Effect of inhibition of glycogen synthase kinase-3 on cardiac hypertrophy during acute pressure overload
- Enhanced Experimental Tumor Metastasis with Age in Senescence-Accelerated Mouse(Molecular and Cell Biology)
- In Vitro Efficacy of a Sterically Stabilized Immunoliposomes Targeted to Membrane Type 1 Matrix Metalloproteinase (MT1-MMP)(Biopharmacy)
- Proteomic Characterization of Angiogenic Endothelial Cells Stimulated with Cancer Cell-Conditioned Medium(Molecular and Cell Biology)
- Myocardial protective effects of University of Wisconsin Solution (UWS), Celsior, and St.Thomas' Hospital Solution (STH) on postischemic donor heart performance
- Giant right atrial myxoma associated with tricuspid regurgitation
- Effect of chronic hypoxia on left ventricular function in rats
- Clinical experiences with Transmyocardial Laser Revascularization in 5 patients ; 6-month follow-up
- Isolation of a Novel Peptide Homing to Tumor-Derived Neovasculature That Suppresses Tumor Growth
- Enhancement of Anticancer Activity in Antineovascular Therapy Is Based on the Intratumoral Distribution of the Active Targeting Carrier for Anticancer Drugs(Biopharmacy)
- Autitumor Activity of 5'-O-Dipalmitoylphosphatidyl 2'-C-Cyano-2'-deoxy-1-β-D-arabino-pentofuranosylcytosine Is Enhanced by Long-Circulating Liposomalization
- Inhibitory Effect of Green Tea Polyphenols on Membrane-Type 1 Matrix Metalloproteinase, MT1-MMP(Analytical Biochemistry)
- 3 Nano-size Liposomes can Specifically Target Ischemic/Reperfused Myocardium(Latest Development of Nanotechnology Revolutionizes Treatments of Cardiovascular Diseases,Topic 3 (TP-3) (H),The 73rd Annual Scientific Meeting of The Japanese Circulation Societ
- Digital Radiographic Quantification of Myocardial Blood Flow Around a Transmyocardial Laser Channel in Rabbit Hearts
- Inhibition of Akt (ser473) Phosphorylation and Rapamycin-Resistant Cell Growth by Knockdown of Mammalian Target of Rapamycin with Small Interfering RNA in Vascular Endothelial Growth Factor Receptor-1-Targeting Vector
- Identification of oligopeptides binding to peritoneal tumors of gastric cancer
- Antineovascular therapy with angiogenic vessel-targeted polyethyleneglycol-shielded liposomal DPP-CNDAC
- Chemoprevention of Tumor Metastasis by Liposomal β-Sitosterol Intake(Molecular and Cell Biology)
- Chronopharmacologic Cancer Treatment with an Angiogenic Vessel-Targeted Liposomal Drug(Biopharmacy)
- Antitumor Activity of Liposomal Naphthoquinone Esters Isolated from Thai Medicinal Plant : Rhinacanthus nasutus KURZ.(Biopharmacy)
- Induction of Apoptosis in Tumor Cells by Three Naphthoquinone Esters Isolated from Thai Medicinal Plant : Rhinacanthus nasutus KURZ(Pharmacognosy)
- Cancer Chemotherapy by Liposomal 6-[[2-(Dimethylamino)ethyl]amino]-3-hydroxy-7H-indeno [2,1-c] quinolin-7-one Dihydrochioride (TAS-103), a Novel Anti-cancer Agent(Miscellaneous)
- Potential Usage of Liposomal 4β-Aminoalkyl-4'-0-demethyl-4-desoxypodophyllotoxin (TOP-53) for Cancer Chemotherapy
- Proapoptotic Action of p53-Tom5 in p53-Resistant A549 Human Non-small Cell Lung Cancer Cells through Direct Mitochondrial Dysfunction
- Mitral Valve Repair for 52 Patients with Severe Left Ventricular Dysfunction
- Nanoparticle-Mediated Delivery of Anticancer Agents to Tumor Angiogenic Vessels
- Systemic Delivery of Small Interfering RNA by Use of Targeted Polycation Liposomes for Cancer Therapy