Isolation of a Novel Peptide Homing to Tumor-Derived Neovasculature That Suppresses Tumor Growth
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概要
- 論文の詳細を見る
Novel peptides homing to angiogenic vessels were recently isolated from a phage-displayed random pentadecapeptide library, and peptides having WRP sequence showed tumor growth suppression. In this study, we observed that another novel sequence, PVVLFPLH, suppressed tumor growth in vivo. Through the study of tumor growth suppression by the 5-mer peptides derived from this sequence, we determined the epitope sequence to be LFPLH. LFPLH, but not the shuffled peptide FHLLP, suppressed the migration of vascular endothelial growth factor-stimulated human umbilical vein endothelial cells. Interestingly, growth suppression of LFPLH against the cells as well as tumor cells was not observed in vitro. Therefore LFPLH may function to induce tumor dormancy through inhibition of angiogenesis.
- 公益社団法人日本薬学会の論文
- 2002-07-01
著者
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ASAI Tomohiro
Department of Cardiovascular Surgery, Okayama University Graduate School of Medicine, Dentistry, and
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OKU Naoto
Department of Radiobiochemistry, School of Pharmaceutical Sciences, University of Shizuoka
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奥 直人
Dep. Of Medical Biochemistry School Of Pharmaceutical Sciences Univ. Of Shizuoka
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Oku Naoto
静岡県立大学 薬学部
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Oku N
Univ. Shizuoka Shizuoka Jpn
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Oku Naoto
Department Of Medical Biochemistry And Coe Program In The 21st Century University Of Shizuoka School
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Ogino Koichi
Molecular Medical Science Institute Otsuka Pharmaceutical Co. Ltd.
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Asai Tomohiro
Department Of Medical Biochemistry And Global Coe University Of Shizuoka School Of Pharmaceutical Sc
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Asai T
Department Of Medical Biochemistry And Coe Program In The 21st Century University Of Shizuoka School
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Asai Tomohiro
Department Of Cardiovascular Surgery Okayama University Graduate School Of Medicine Dentistry And Ph
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Taki Takao
Molecular Medical Science Institute Otsuka Pharmaceutical Co. Ltd.
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Taki T
Molecular Medical Science Institute Otsuka Pharmaceutical Co. Ltd.
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Asai Tomohiro
Department Of Medical Biochemistry University Of Shizuoka School Of Pharmaceutical Sciences
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FUKATSU Hideto
Department of Medical Biochemistry, University of Shizuoka School of Pharmaceutical Sciences
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KUROMI Koichi
Department of Medical Biochemistry, University of Shizuoka School of Pharmaceutical Sciences
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TANAKA Michinori
Molecular Medical Science Institute, Otsuka Pharmaceutical Co., Ltd.
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奥 直人
静岡県立大学薬学部医薬生命科学教室
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Kubota Koji
Dep. Of Surgery Shinshu Univ. School Of Medicine
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Kuromi Koichi
Department Of Drug And Food Science Shizuoka Institute Of Environment And Hygiene
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Fukatsu H
Department Of Medical Biochemistry University Of Shizuoka School Of Pharmaceutical Sciences
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Tanaka Michinori
Molecular Medical Science Institute Otsuka Pharmaceutical Co. Ltd.
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OKU Naoto
Department of Biochemistry, Faculty of Pharmaceutical Sciences, Setsunan University
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