PEGylation of Liposome Decreases the Susceptibility of Liposomal Drug in Cancer Photodynamic Therapy (Communication to the Editor)
スポンサーリンク
概要
- 論文の詳細を見る
For the purpose of the avoidance of reticuloendothelial system (RES)-trapping, liposome entrapped benzoporphyrin derivative monoacid ring A (BPD-MA), which is used for cancer photodynamic therapy (PDT), was modified with polyethylene glycol (PEG-LipBPD-MA). Tumor accumulation of BPD-MA at 3h after injection with PEG-LipBPD-MA in Meth A-sarcomabearing mice was significantly higher than that after injection with non-modified liposomal BPD-MA (Cont-LipBPD-MA) as expected. On the contrary, significant tumor growth suppression after PDT was observed only for Cont-LipBPD-MA but not for PEG-LipBPD-MA. Thus, PEGylation enhances the passive targeting of liposomal BPD-MA in tumor, but decreases the susceptibility of the drug in PDT.
- 公益社団法人日本薬学会の論文
- 2004-03-01
著者
-
NAMBA Yukihiro
Nippon Fine Chemical Co., Ltd.,
-
Namba Yukihiro
静岡県立大学 薬学部
-
Namba Yukihiro
静岡県立大学 医薬生命化学
-
Namba Yukihiro
Nippon Fine Chemical Co.
-
奥 直人
Dep. Of Medical Biochemistry School Of Pharmaceutical Sciences Univ. Of Shizuoka
-
Oku Naoto
静岡県立大学 薬学部
-
Oku Naoto
University Of Shizuoka School Of Pharmaceutical Sciences
-
Oku N
Univ. Shizuoka Shizuoka Jpn
-
Namba Y
Nippon Fine Chemical Co. Ltd.
-
MAEDA Noriyuki
Radio Access Network Development Department, NTT DOCOMO, INC.
-
Maeda Noriyuki
Radio Access Network Development Department Ntt Docomo Inc.
-
Maeda N
Department Of Medical Biochemistry And Coe Program In The 21st Century School Of Pharmaceutical Scie
-
奥 直人
静岡県立大学薬学部医薬生命科学教室
-
ICHIKAWA Kanae
University of Shizuoka School of Pharmaceutical Sciences
-
HIKITA Tomoya
University of Shizuoka School of Pharmaceutical Sciences
-
MAEDA Noriyuki
University of Shizuoka School of Pharmaceutical Sciences
-
TAKEUCHI Yoshito
University of Shizuoka School of Pharmaceutical Sciences
-
Ichikawa Kanae
Department Of Medical Biochemistry And Coe Program In The 21st Century School Of Pharmaceutical Scie
-
Oku Naoto
University Of Shizuoka Graduate School Of Pharmaceutical Sciences
関連論文
- Argonaute2ノックダウンによる腫瘍新生血管傷害療法の開発(誌上シンポジウム)
- DDS製剤開発のためのイメージング技術
- 0312 胃癌腹膜播種に対する化学療法とBiopanningを用いた標的化(胃診断6(腹膜播種),一般演題,第61回日本消化器外科学会定期学術総会)
- ポリカチオン化ホスファチジン酸コンジュゲートの合成と遺伝子導入キャリヤーとしての機能評価
- Magnetic Resonance Lymphography of Profundus Lymph Nodes with Liposomal Gadolinium-Diethylenetriamine Pentaacetic Acid
- PREPARATION OF RES-AVOIDING LIPOSOMES
- リポソーム化 CNDAC リン脂質誘導体による肺転移癌治療
- CNDACリン脂質誘導体含有RES回避リポソームの抗腫瘍効果
- シアル酸を含有しない糖脂質とインフルエンザA型ウイルスの結合
- 第3回国際O-CHA学術会議(ICOS2007)
- Enhanced Experimental Tumor Metastasis with Age in Senescence-Accelerated Mouse(Molecular and Cell Biology)
- DDSを利用した分子イメージングに向けて
- 腫瘍新生血管を標的としたリポソーム製剤の開発と評価
- 表面修飾リポソームの経口ワクチンへの応用
- モノカルボン酸系薬物の脂質膜透過機構の解析 - Carrier Mediated like Uptake of Salicylic Acid by Liposomes -
- The Synthesis and in Vitro and in Vivo Stability of 5-Fluorouracil Prodrugs Which Possess Serum Albumin Binding Potency
- Increased Expression of Hsp70 for Resistance to Deuterium Oxide in a Yeast Mutant Cell Line
- EXPRESSION OF STRESS PROTEIN IN YEAST WHICH IS RESISTANT TO LOW TEMPERATURE AND DEUTERIUM OXIDE
- Chaperonin-Repairable Subtle Incompleteness of Protein Assembly Induced by a Substitution of Hydrogen with Deuterium : Effect of GroE on Deuterated Ribulose 1,5-Bisphosphate Carboxylase : PROTEINS, ENZYMES AND METABOLISM
- Therapeutic Efficacy of 5-Fluorouracil Prodrugs Using Endogenous Serum Proteins as Drug Carriers : A New Strategy in Drug Delivery System
- Proteomic Characterization of Angiogenic Endothelial Cells Stimulated with Cancer Cell-Conditioned Medium(Molecular and Cell Biology)
- siRNA体内動態のPET解析と新規ベクターの開発
- Argonaute2 (Ago2) 標的siRNA細胞内導入による細胞増殖抑制に関する検討
- 腫瘍新生血管標的化リポソーム (特集 抗がん剤のDrug Delivery System)
- 標的化リポソｰムを用いた腫瘍新生血管傷害療法
- ファージディスプレイペプチドライブラリー-標的化のための低分子プローブの簡単な作製法-
- Field Experiments on Throughput Performance above 100 Mbps in Forward Link for VSF-OFCDM Broadband Wireless Access(Multi-carrier Signal Processing Techniques for Next Generation Mobile Communications-Part 2)
- Likelihood Function for QRM-MLD Suitable for Soft-Decision Turbo Decoding and Its Performance for OFCDM MIMO Multiplexing in Multipath Fading Channel(MIMO)(Multi-carrier Signal Processing Techniques for Next Generation Mobile Communicatio
- Therapeutic Effect of Reticuloendothelial System (RES)-Avoiding Liposomes Containing a Phospholipid Analogue of 5-Fluorouracil, Dipalmitoylphosphatidylfluorouridine, in Meth A Sarcoma-Bearing Mice
- 薬学共用試験--CBTとOSCE (特集 「参加型」実務実習で次世代を育てる) -- (実習参加学生の資質の確保に向けて)
- Adaptive Selection of Surviving Symbol Replica Candidates for Quasi-Maximum Likelihood Detection Using M-Algorithm with QR-Decomposition for OFDM MIMO Multiplexing
- Accurate FFT Processing Window Timing Detection Based on Maximum SIR Criterion in OFCDM Wireless Access(Multi-carrier Signal Processing Techniques for Next Generation Mobile Communications-Part 2)
- Variable Spreading Factor-OFCDM with Two Dimensional Spreading that Prioritizes Time Domain Spreading for Forward Link Broadband Wireless Access(Multi-carrier Signal Processing Techniques for Next Generation Mobile Communications-Part 2)
- 海馬苔状線維-CA3錐体細胞間での長期増強に対する亜鉛の作用
- β-Thujaplicin Zinc Chelate Induces Apoptosis in Mouse High Metastatic Melanoma B16BL6 Cells
- Role of Sialylglycoconjugate(s) in the Initial Phase of Metastasis of Liver-metastatic RAW117 Lymphoma Cells
- Cell-Nuclear Accumulation of 72-kDa Stress Protein Induced by Dimethylated Arsenics
- Cell-nuclear Accumulation of Stress Protein (Hsp72) Induced by Dimethylarsenics (Proceedings of the 20th Symposium on Toxicology and Environmental Health)
- 温度感受性リポソームによる腫瘍壊死因子(TNF)の組織特異的デリバリーのための基礎研究
- RGD構造類似体アルギニルアミノヘキサン酸およびその修飾リポソームによる癌転移抑制
- Suppressed Permeation of Linoleic Acid in a Liposomal Formulation through Reconstructed Skin Tissue(Biopharmacy)
- Skin Whitening Effect of Linoleic Acid Is Enhanced by Liposomal Formulations (Biopharmacy)
- Isolation of a Novel Peptide Homing to Tumor-Derived Neovasculature That Suppresses Tumor Growth
- サポニンによる好中球の活性化
- DNA-Strand Breaks Induced by Dimethylarsinic Acid, a Metabolite of Inorganic Arsenics, Are Strongly Enhanced by Superoxide Anion Radicals
- 嗅内野刺激に伴う扁桃体外側核からの亜鉛の放出
- リポソーム化 RGD による癌転移抑制
- Functional role of sialyl lewis X and fibronectin-derived RGDS peptide analogue on tumor cell arrest in lungs followed by extravasation.
- Enhancement of Anticancer Activity in Antineovascular Therapy Is Based on the Intratumoral Distribution of the Active Targeting Carrier for Anticancer Drugs(Biopharmacy)
- Influence of Histidine on Zinc Transport into Rat Brain
- Transport and Action of Cadmium and Zinc in Rat Brain(PROCEEDINGS OF 24TH SYMPOSIUM ON TOXICOLOGY AND ENVIRONMENTAL HEALTH)
- Autitumor Activity of 5'-O-Dipalmitoylphosphatidyl 2'-C-Cyano-2'-deoxy-1-β-D-arabino-pentofuranosylcytosine Is Enhanced by Long-Circulating Liposomalization
- Application of Long-Circulating Liposomes to Cancer Photodynamic Therapy
- PETによりがんの転移過程を観察する
- Effect of Freeze-Thawing on Phospholipid/Surfactant Mixed Bilayers
- 転移性癌細胞の生体内動態におけるインテグリンの関与 : PETを用いた解析
- Permeability Change of Liposomal Membrane Induced by Interleukin-1∂
- A New and Known Cytotoxic Aryltetralin-Type Lignans from Stems of Bursera graveolens
- 高分子デリバリーを目的とした温度感受性リポソームの開発
- PROTON-INDUCED MEMBRANE FUSION OF LIPOSOMES CONTAINING pH-SENSITIVE POLYMER
- Involvement of Metabolic Methylation in Arsenic-Induced Mutagenesis for Mammalian Cells (Proceedings of the 22nd Symposium on Toxicology and Environmental Health)
- DNA Single-Strand Breaks in L-132 Cells Resulting from Inhibition of Repair Polymerization Shortly after Exposure to Dimethylarsinic Acid
- Differential Effect of UV-B and UV-C on DNA Damage in L-132 Cells
- Dimethylarsenics Reveal DNA Damage Induced by Superoxide Anion Radicals
- Mode of Gene Damage Induced by Exposure to UVB and Some Radical Species (Proceedings of the 20th Symposium on Toxicology and Environmental Health)
- Gene Damage in Human Pulmonary Cultured Cells Induced by Dimethylarsenics (Proceedings of the 19th Symposium on Toxicology and Environmental Health)
- Interaction between Dimethylarsenics and Active Oxygen Species in the Induction of Gene Damage (Proceedings of the 19th Symposium on Toxicology and Environmental Health)
- Antineovascular therapy with angiogenic vessel-targeted polyethyleneglycol-shielded liposomal DPP-CNDAC
- Chemoprevention of Tumor Metastasis by Liposomal β-Sitosterol Intake(Molecular and Cell Biology)
- Chronopharmacologic Cancer Treatment with an Angiogenic Vessel-Targeted Liposomal Drug(Biopharmacy)
- Antitumor Activity of Liposomal Naphthoquinone Esters Isolated from Thai Medicinal Plant : Rhinacanthus nasutus KURZ.(Biopharmacy)
- Induction of Apoptosis in Tumor Cells by Three Naphthoquinone Esters Isolated from Thai Medicinal Plant : Rhinacanthus nasutus KURZ(Pharmacognosy)
- PEGylation of Liposome Decreases the Susceptibility of Liposomal Drug in Cancer Photodynamic Therapy (Communication to the Editor)
- Cancer Chemotherapy by Liposomal 6-[[2-(Dimethylamino)ethyl]amino]-3-hydroxy-7H-indeno [2,1-c] quinolin-7-one Dihydrochioride (TAS-103), a Novel Anti-cancer Agent(Miscellaneous)
- Potential Usage of Liposomal 4β-Aminoalkyl-4'-0-demethyl-4-desoxypodophyllotoxin (TOP-53) for Cancer Chemotherapy
- 奨励賞受賞 五十里彰氏の業績
- siRNA実用化の鍵をにぎるDDS
- Antiproliferative naphthoquinone esters from Rhinacanthus nasutus Kurz. roots on various cancer cells
- Antenna Diversity Reception Appropriate for MMSE Combining in Frequency Domain for Forward Link OFCDM Packet Wireless Access(Special Issue on Mobile Multimedia Communications)
- Pilot Channel Assisted MMSE Combining in Forward Link for Broadband OFCDM Packet Wireless Access(Special Section on Multi-dimensional Mobile Information Networks)
- Hepatocyte Growth Factor and Transforming Growth Factor-β Stimulate both Cell Growth and Migration of Human Gastric Adenocarcinoma Cells^1
- Performance Comparison of Channel Interleaving Methods in Frequency Domain for VSF-OFCDM Broadband Wireless Access in Forward Link(Special Issue on Multiple Access and Signal Transmission Techniques for Future Mobile Communications)
- 初年度の薬学共用試験を終えて
- 発光・蛍光インビボイメージング装置
- Reconstitution of the Na^+/H^+ Antiporter : A New Method for the Determination of H^+ Efflux from Na^+/H^+ Antiporter-Reconstituted Vesicles
- バイオイメージングは未知の分野を切り拓く
- ラット脳腫瘍における各種元素の取込
- 脳内亜鉛恒常性の変化とけいれん発作
- てんかん発作と脳内亜鉛動態
- ラット脳の発育時における亜鉛代謝と学習との関係
- マウス脳内への亜鉛取り込みにおけるヒスチジンの影響
- ラット脳内へのマンガン取り込みにおけるトランスフェリンの役割
- トランスフェリン欠損マウスの脳における鉄の取込
- ラット嗅覚路におけるマンガンの動態と役割
- シナプス神経伝達における亜鉛の役割 : 学習・記憶との関係において
- マンガンのマウス大脳基底核集積機構に関する研究
- シナプスにおける亜鉛の生理作用
- 亜鉛不足と行動・学習との関係
- 2SG-04 脂質・DNA複合体の動的構造と細胞内核酸送達能(2SG 生命分子の揺らぎを探る新たなアプローチ,日本生物物理学会第49回年会(2011年度))
- 東日本大震災と第131年会(静岡)