Inhibitory Effect of Green Tea Polyphenols on Membrane-Type 1 Matrix Metalloproteinase, MT1-MMP(Analytical Biochemistry)
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概要
- 論文の詳細を見る
Matrix metalloproteinases (MMPs), especially membrane-type 1 matrix metalloproteinase (MT1-MMP), which generates an active form of MMP-2 from proMMP-2, are deeply involved in angiogenesis as well as in tumor cell migration and metastasis. To obtain a specific inhibitor for MT1-MMP, we screened a number of natural and synthetic compounds using recombinant human MMP-2, MMP-7, and soluble MT1-MMP in a fluorogenic peptide cleavage assay. (-)-Epigallocatechin 3-0-gallate (EGCG) followed by (-)-epigallocatechin 3,5-di-O-gallate and epitheaflagallin 3-O-gallate, was found to have potent and distinct inhibitory activity against MT1-MMP. Therefore, we investigated the effect of EGCG on the suppression of MMP-2 activation as determined by gelatin zymography, and observed that the active form of MMP-2 in the conditioned medium of human umbilical vein endothelial cells was decreased in the presence of EGCG. The results suggest the possibility that tea polyphenols suppress tumor growth through the suppression of angiogenesis.
- 公益社団法人日本薬学会の論文
- 2003-09-01
著者
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ASAI Tomohiro
Department of Cardiovascular Surgery, Okayama University Graduate School of Medicine, Dentistry, and
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OKU Naoto
Department of Radiobiochemistry, School of Pharmaceutical Sciences, University of Shizuoka
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Hashimoto F
Kagoshima Univ. Kagoshima
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Oku Naoto
Department Of Medical Biochemistry And Coe Program In The 21st Century University Of Shizuoka School
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Shiono Yuki
School Of Agriculture Tokai Univ.
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Asai Tomohiro
Department Of Medical Biochemistry And Global Coe University Of Shizuoka School Of Pharmaceutical Sc
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Asai T
Department Of Medical Biochemistry And Coe Program In The 21st Century University Of Shizuoka School
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Asai Tomohiro
Department Of Cardiovascular Surgery Okayama University Graduate School Of Medicine Dentistry And Ph
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Hashimoto Fumio
Department of Horticultural Science, Faculty of Agriculture, Kagoshima University
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YAHARA Shoji
Graduate School of Pharmaceutical Sciences, Kumamoto University
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AKIZAWA Toshifumi
Department of Analytical Chemistry, Faculty of Pharmaceutical Sciences, Setsunan University
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Asai Tomohiro
Department Of Medical Biochemistry University Of Shizuoka School Of Pharmaceutical Sciences
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MATSUKAWA Motomi
Department of Analytical Chemistry, Faculty of Pharmaceutical Sciences, Setsunan University
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YAMAKAWA Satoru
Department of Medical Biochemistry and COE Program in the 21st Century, University of Shizuoka, Scho
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Hashimoto Fumio
Department Of Horticultural Science Faculty Of Agriculture Kagoshima University
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Yahara Shoji
Graduate School Of Pharmaceutical Science Kumamoto University
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Yahara Shoji
Graduate School Of Pharmaceutical Sciences Kumamoto University
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Akizawa Toshifumi
Department Of Analytical Chemistry Faculty Of Pharmaceutical Sciences Setsunan University
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Matsukawa M
Department Of Analytical Chemistry Faculty Of Pharmaceutical Sciences Setsunan University
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Yahara Shoji
Graduate School Of Pharmaceutical Sciences Kumamoto Univ.
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Yamakawa S
Department Of Medical Biochemistry And Coe Program In The 21st Century University Of Shizuoka School
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Matsukawa Motomi
Department Of Analytical Chemistry Faculty Of Pharmaceutical Sciences Setsunan University
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OKU Naoto
Department of Biochemistry, Faculty of Pharmaceutical Sciences, Setsunan University
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