Anti-herpes Virus Activity of Fabaceous Triterpenoidal Saponins
スポンサーリンク
概要
- 論文の詳細を見る
Anti-herpes simplex virus type 1 (HSV-1) activity of oleanane-tpe triterpenoidal saponins obtained from some fabaceous plants were examined. Among sophoradiol glycosides, the order of potency was kaikasaponins III>I≫sophoradiol monoglucurnoide. It was suggested that the trisaccharide group showed greater action than the disaccharide group. Neither the monoglucuronide of sophordadiol nor that of soyasapogenol B showed activity. Among the trisaccharide group of soyasapogenol B, the order of activity was azukisaponin V>soyasaponin II>astragaloside VIII≫soyasaponin I. Therefore, the saponin having a glucosyl unit in the central sugar moiety seemed to show greater action. In comparison with the activities for a group having the same trisacchardie, the potency of the sapogenol moieties was found to be in the order of soyasapogenol E>sophoradiol≫soyasapogenol B. Hence, the carbonyl group at C-22 would be more effective than the hydroxyl group in anti-HSV-1 activity, while the hydroxyl group at C-24 could reduce the activity.
- 社団法人日本薬学会の論文
- 2000-07-01
著者
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Yokomizo Kazumi
Laboratory of Presymptomatic Medical Pharmacology, Faculty of Pharmaceutical Sciences, Sojo Universi
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Kinjo Junei
Department Of Pharmacognosy Faculty Of Pharmaceutical Sciences Fukuoka University
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Kinjo Junei
熊本大学 薬
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Hirakawa Tomoki
Faculty Of Pharmaceutical Sciences Kumamoto University
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Hirakawa Tomoki
福岡大学 薬
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NOHARA Toshihiro
Laboratory of Natural Medicines, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University
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UYEDA Masaru
Laboratory of Pharmaceutical Microbiology, Faculty of Medical and Pharmaceutical Sciences, Kumamoto
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Uyeda Masaru
Laboratory Of Pharmaceutical Microbiology Faculty Of Medical And Pharmaceutical Sciences Kumamoto Un
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Uyeda Masaru
Shokei University
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Yokomizo K
Kumamoto Univ. Kumamoto Jpn
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Shiono Yuki
School Of Agriculture Tokai Univ.
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Udayama M
Kumamoto Univ. Kumamoto Jpn
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Yokomizo Kazumi
Laboratory Of Pharmaceutical Microbiology Faculty Of Medical And Pharmaceutical Sciences Kumamoto Un
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Yokomizo Kazumi
Faculty Of Pharmaceutical Sciences Kumamoto University
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KINJO Junei
Laboratory of Natural Medicines, Faculty of Pharmaceutical Sciences, Kumamoto University
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HIRAKAWA Tomoki
Laboratory of Natural Medicines, Faculty of Pharmaceutical Sciences, Kumamoto University
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SHII Yuichi
Laboratory of Natural Medicines, Faculty of Pharmaceutical Sciences, Kumamoto University
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Uyeda Masaru
Laboratory Of Medicinal Microbiology Faculty Of Pharmaceutical Sciences Kumamoto University
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Nohara Toshihiro
Laboratory Of Medicinal Microbiology Faculty Of Pharmaceutical Sciences Kumamoto University
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Udayama Manabu
Faculty Of Pharmaceutical Sciences Kumamoto University
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Hirose Toshiharu
Faculty Of Pharmaceutical Sciences Kanazawa University
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Uyeda Masaru
Department Of Pharmaceutical Microbiology Faculty Of Medical And Pharmaceutical Sciences Kumamoto Un
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Yahara Shoji
Graduate School Of Pharmaceutical Sciences Kumamoto University
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Kinjyo Junei
Faculty Of Pharmaceutical Sciences Kumamoto University
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Yahara Shoji
Graduate School Of Pharmaceutical Sciences Kumamoto Univ.
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Yasuda Shin
Tokai Univ. School Of Agriculture
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