Inhibition of Topoisomerases by Antitumor Prostaglandins.
スポンサーリンク
概要
- 論文の詳細を見る
Topoisomerase II from human placenta was strongly inhibited by prostaglandins such as ⊿^<12,14>-PGJ_2,⊿^<12>-PGJ_2,PGA_2,and PGA_1,which have an antitumor activity. The topoisomerase II inhibitions by these prostaglandins were dose-dependent and IC_<50> values of ⊿^<12,14>-PGJ_2,⊿^<12>-PGJ_2,PGA_2,and PGA_1 were 22μM, 74μM, 75μM, and 98μM, respectively. Topoisomerase I from calf thymus gland was inhibited by ⊿^<12,14>-PGJ_2,⊿^<12>-PGJ_2,and PGA_2,but not inhibited by other prostaglandins even at high concentrations. Only the prostaglandins having the antitumor activity inhibited topoisomerase II. The results suggest that the antitumor activity of prostaglandins may be related, at least in part, to inhibition of topoisomerase II in tumor cells.
- 社団法人日本農芸化学会の論文
- 1998-10-23
著者
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UYEDA Masaru
Laboratory of Pharmaceutical Microbiology, Faculty of Medical and Pharmaceutical Sciences, Kumamoto
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Uyeda Masaru
Laboratory Of Pharmaceutical Microbiology Faculty Of Medical And Pharmaceutical Sciences Kumamoto Un
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Uyeda Masaru
熊本大学 薬 薬学微生物
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Uyeda Masaru
Laboratory Of Medicinal Microbiology Faculty Of Pharmaceutical Sciences Kumamoto University
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SUZUKI KEITAROU
Laboratory of Medicinal Microbiology, Faculty of Pharmaceutical Sciences Kumamoto University
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Suzuki Keitarou
Laboratory Of Medicinal Microbiology Faculty Of Pharmaceutical Sciences Kumamoto University
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Udayama Manabu
Faculty Of Pharmaceutical Sciences Kumamoto University
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SHONO Fumiko
Laboratory of Medicinal Microbiology, Faculty of Pharmaceutical Sciences, Kumamoto University
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Shono Fumiko
Laboratory Of Medicinal Microbiology Faculty Of Pharmaceutical Sciences Kumamoto University
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Suzuki Keitarou
熊本大学 薬 薬学微生物
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