Selectively Increased Production of Acidic Actinomycin Congener, B-1625 FA2β, on Combined Use of Sarcosine and Ferrous Sulfate
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概要
- 論文の詳細を見る
In addition to actinomycins D, X2 and Xoβ, Streptomyces antibioticus No. B-1625 produces minor acidic actinomycin congeners (FA-components). To increase the production of the FA-components, improvement of medium constituents was attempted for both chemically denned and complex media. Addition of trace metals, especially FeSO4, increased FA-components production and, moreover, the addition of sarcosine was found to increase the production of a selected component, B-1625 FA2β. Finally, a complex medium, consisting of starch 3.0, Polypepton 0.1, meat extract 0.1, corn steep liquor 3.0, NaCl 0.3, CaCO3 0.3, sarcosine 0.1 and FeSO4•7H2O 0.05%, was developed for the increased production of FA-components, in particular, the selected component of B-1625 FA2β.
- 社団法人 日本農芸化学会の論文
著者
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Uyeda Masaru
Laboratory Of Medicinal Microbiology Faculty Of Pharmaceutical Sciences Kumamoto University
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Shibata Motoo
Laboratory Of Medicinal Microbiology Faculty Of Pharmaceutical Sciences Kumamoto University
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Fujimoto Yuki
Laboratory Of Medicinal Microbiology Faculty Of Pharmaceutical Sciences Kumamoto University
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Abe Kazuhiro
Laboratory Of Medicinal Microbiology Faculty Of Pharmaceutical Sciences Kumamoto University
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SUZUKI Keitaro
Laboratory of Medicinal Microbiology, Faculty of Pharmaceutical Sciences, Kumamoto University
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MASUDA Kenji
Laboratory of Medicinal Microbiology, Faculty of Pharmaceutical Sciences, Kumamoto University
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