Anti-herpes Virus Activity of Solanum Steroidal Glycosides

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概要

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• Since some Solanum-genus plants have traditionally been used for anti-cancer and anti-herpes agents from olden times, we examined anti-herpes simplex virus type 1 (HSV-1) activity of typical steroidal glycosides with the frameworks of spirostane (including nuatigenin glycoside), furostane, solasodane, tomatidane and ergostane(including dimer) obtained from solanum plants. Among these steroidal glycosides, the spirostanol glycosides were most effective. An inclination was observed for the potency of activity to decrease in the order of spirostane, tomatidane, ergostane, solasodane, nuatigenin type, dimer of ergostane and furostane. It was also suggested that the activity depends on the kind of oligosacchride moiety.

• 社団法人日本薬学会の論文
• 2000-03-01

著者

• Yokomizo Kazumi

  Laboratory of Presymptomatic Medical Pharmacology, Faculty of Pharmaceutical Sciences, Sojo Universi

• 池田 卓也

  Exploratory Research Laboratories Iii Daiichi Pharmaceutical Co. Ltd.

• Nohara T

  Faculty Of Pharmaceutical Sciences Kumamoto University

• IKEDA Tsuyoshi

  Laboratory of Natural Medicines, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University

• NOHARA Toshihiro

  Laboratory of Natural Medicines, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University

• UYEDA Masaru

  Laboratory of Pharmaceutical Microbiology, Faculty of Medical and Pharmaceutical Sciences, Kumamoto

• ZHU Xing-Hua

  Faculty of Medical and Pharmaceutical Sciences, Kumamoto University

• TSUMAGARI Hidetsugu

  Faculty of Medical and Pharmaceutical Sciences, Kumamoto University

• Uyeda Masaru

  Laboratory Of Pharmaceutical Microbiology Faculty Of Medical And Pharmaceutical Sciences Kumamoto Un

• Uyeda Masaru

  Shokei University

• Yokomizo K

  Kumamoto Univ. Kumamoto Jpn

• Zhu Xing-hua

  Faculty Of Medical And Pharmaceutical Sciences Kumamoto University

• Udayama M

  Kumamoto Univ. Kumamoto Jpn

• Ikeda Tsuyoshi

  Faculty Of Medical And Pharmaceutical Science Kumamoto University

• Yokomizo Kazumi

  Laboratory Of Pharmaceutical Microbiology Faculty Of Medical And Pharmaceutical Sciences Kumamoto Un

• Yokomizo Kazumi

  Faculty Of Pharmaceutical Sciences Kumamoto University

• ANDO Jun

  Laboratory of Natural Medicines, Faculty of Pharmaceutical Sciences, Kumamoto University

• MIYAZONO Akiko

  Laboratory of Natural Medicines, Faculty of Pharmaceutical Sciences, Kumamoto University

• ZHU Xing-Hua

  Laboratory of Natural Medicines, Faculty of Pharmaceutical Sciences, Kumamoto University

• TSUMAGARI Hidetsugu

  Laboratory of Natural Medicines, Faculty of Pharmaceutical Sciences, Kumamoto University

• Uyeda Masaru

  Laboratory Of Medicinal Microbiology Faculty Of Pharmaceutical Sciences Kumamoto University

• ANDO Jun

  Faculty of Pharmaceutical Sciences, Kumamoto University

• Nohara Toshihiro

  Laboratory Of Medicinal Microbiology Faculty Of Pharmaceutical Sciences Kumamoto University

• Udayama Manabu

  Faculty Of Pharmaceutical Sciences Kumamoto University

• Uyeda Masaru

  Department Of Pharmaceutical Microbiology Faculty Of Medical And Pharmaceutical Sciences Kumamoto Un

• Ando J

  Faculty Of Pharmaceutical Sciences Kumamoto University

• Ikeda T

  Kumamoto Univ. Kumamoto Jpn

• Miyazono Akiko

  Laboratory Of Natural Medicines Faculty Of Pharmaceutical Sciences Kumamoto University

• Tsumagari Hidetsugu

  Faculty Of Medical And Pharmaceutical Sciences Kumamoto University

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