Synthesis and Pharmacological Activities of Novel Bicyclic Thiazoline Derivatives as Hepatoprotective Agents. II. (7-Alkoxycarbonyl-2,3,5,6-tetrahydropyrrolo[2,1-b]thiazol-3-ylidene)acetamide Derivatives
スポンサーリンク
概要
- 論文の詳細を見る
A series of exomethylenic bicyclic thiazoline derivatives (3a-i) was synthesized and evaluated for hepatoprotective activity against galactosamine-induced and monoclonal antibody-induced acute liver injuries in rats. The structure-activity relationships were investigated. Among the compounds synthesized, N-methyl-(7-isopropoxycarbonyl-6,6-dimethyl-2,3,5,6-tetrahydropyrrolo[2,1-b]thiazol-3-ylidene)acetamide (3i) exhibited the most potent hepatoprotective activity. This compound suppressed galactosamine-induced hepatic injury at 100 mg/kg by oral administration and further prevented monoclonal antibody-induced hepatic injury at 30 mg/kg by intraperitoneal injection, as judged from the changes in serum transaminase activities.
- 社団法人日本薬学会の論文
- 1995-07-15
著者
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本田 優子
Exploratory Research Laboratories Iii Daiichi Pharmaceutical Co. Ltd.
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池田 卓也
Exploratory Research Laboratories Iii Daiichi Pharmaceutical Co. Ltd.
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榑林 陽一
Exploratory Research Laboratories Iii Daiichi Pharmaceutical Co. Ltd.
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長谷川 雅司
Exploratory Research Laboratories III, Daiichi Pharmaceutical Co., Ltd.,
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中山 敦
Exploratory Research Laboratories III, Daiichi Pharmaceutical Co., Ltd.,
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横濱 秀一
Exploratory Research Laboratories III, Daiichi Pharmaceutical Co., Ltd.,
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細上 徹
Exploratory Research Laboratories III, Daiichi Pharmaceutical Co., Ltd.,
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下東 義正
Exploratory Research Laboratories III, Daiichi Pharmaceutical Co., Ltd.,
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井手 照一郎
Exploratory Research Laboratories III, Daiichi Pharmaceutical Co., Ltd.,
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鈴木 範夫
Exploratory Research Laboratories III, Daiichi Pharmaceutical Co., Ltd.,
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Honda Yuko
Exploratory Research Laboratories Iii Daiichi Pharmaceutical Co. Ltd.
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鈴木 範夫
Exploratory Research Laboratories Iii Daiichi Pharmaceutical Co. Ltd.
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Ikeda Tsuyoshi
Faculty Of Medical And Pharmaceutical Science Kumamoto University
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Kurebayashi Y
Exploratory Research Laboratories Iii Daiichi Pharmaceutical Co. Ltd.
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細上 徹
第一製薬株式会社 (東京研究開発センター) 探索第三研究所
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中山 敦
Exploratory Research Laboratories Iii Daiichi Pharmaceutical Co. Ltd.
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Nakayama Atsushi
Exploratory Research Laboratories Iii Daiichi Pharmaceutical Co. Ltd.
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細上 徹
Exploratory Research Laboratories Iii Daiichi Pharmaceutical Co. Ltd.
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横濱 秀一
Exploratory Research Laboratories Iii Daiichi Pharmaceutical Co. Ltd.
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下東 義正
Exploratory Research Laboratories Iii Daiichi Pharmaceutical Co. Ltd.
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長谷川 雅司
Exploratory Research Laboratories Iii Daiichi Pharmaceutical Co. Ltd.
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井手 照一郎
Exploratory Research Laboratories Iii Daiichi Pharmaceutical Co. Ltd.
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Suzuki N
Graduate School Of Pharmaceutical Sciences Tohoku University
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Ikeda T
Kumamoto Univ. Kumamoto Jpn
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下東 義正
New Product Research Laboratories Iii Daiichi Pharmaceutical Co. Ltd.
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Honda Y
Nihon Univ. Chiba Jpn
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Hasegawa M
Faculty Of Pharmaceutical Sciences Kanazawa University
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細上 徹
New Product Research Laboratories Iii Daiichi Pharmaceutical Co. Ltd.
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