Synthesis of Antimicrobial Agents. I. Synthesis and Antimicrobial Activities of Thiazoloquinoline Derivatives
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概要
- 論文の詳細を見る
A series of substituted thiazolo [4,5-g]-, [5,4-g]-, [4,5-h]-and [5,4-h] quinoline carboxylic acids has been prepared by the following two methods with the aim of providing new antimicrobial drugs. One of the synthetic methods has been carried out through successive steps of condensation of aminobenzothiazole with diethyl ethoxymethylenemalonate, Gould-Jacobs reaction, N-alkylation and hydrolysis. The other is thiazole ring cyclization of ortho-aminated mercaptoquinoline. These compounds prepared in this work were evaluated for antimicrobial activities in vitro. 9-Chloro-8-ethyl-5,8-dihydro-5-oxothiazolo-[4,5-g] quinoline-6-carboxylic acid (28b) showed the highest activity.
- 公益社団法人日本薬学会の論文
- 1979-01-25
著者
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田中 良明
Research Institute, Daiichi Seiyaku Co., Ltd.
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鈴木 範夫
Research Institute, Daiichi Seiyaku Co., Ltd.
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鈴木 範夫
Exploratory Research Laboratories III, Daiichi Pharmaceutical Co., Ltd.,
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鈴木 範夫
Exploratory Research Laboratories Iii Daiichi Pharmaceutical Co. Ltd.
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田中 良明
Research Institute Daiichi Seiyaku Co. Ltd.
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鈴木 範夫
Research Institute Daiichi Seiyaku Co. Ltd.
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堂森 廉三
Research Institute Daiichi Seiyaku Co. Ltd.
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