Synthesis of Antimicrobial Agents. VI. Studies on the Synthesis of Furo [3,2-b] [1,8] naphthyridine Derivatives

スポンサーリンク

概要

• 論文の詳細を見る

• As a part of our search for new antibacterial agents, 5-ethyl-8-oxo-5,8-dihydrofuro [3,2-b]-[1,8] naphthyridine-7-carboxylic acid and its 2,3-dihydrofuro derivative, the 4-aza analogue of droxacin, were synthesized and their antibacterial activities were tested. Both compounds exhibited high antibacterial activities and a broad antibacterial spectrum. In an attempt to find a suitable method for industrial-scale synthesis of these compounds, several methods for the furan ring cyclization of 6,7-disubstituted 1,8-naphthyridine-3-carboxylate derivatives were compared.

• 社団法人日本薬学会の論文
• 1984-12-25

著者

• 田中 良明

  松島病院大腸肛門病センター

• 鈴木 和徳

  松島病院大腸肛門病センター

• 田中 良明

  松島病院外科

• 田中 良明

  Research Institute, Daiichi Seiyaku Co., Ltd.

• 鈴木 範夫

  Research Institute, Daiichi Seiyaku Co., Ltd.

• 早川 勇夫

  Research Institute, Daiichi Seiyaku Co., Ltd.

• 鈴木 和徳

  Research Institute, Daiichi Seiyaku Co., Ltd.

• 鈴木 範夫

  Exploratory Research Laboratories III, Daiichi Pharmaceutical Co., Ltd.,

• 鈴木 範夫

  Exploratory Research Laboratories Iii Daiichi Pharmaceutical Co. Ltd.

• 田中 良明

  Research Institute Daiichi Seiyaku Co. Ltd.

• 鈴木 範夫

  Research Institute Daiichi Seiyaku Co. Ltd.

• 早川 勇夫

  第一製薬

関連論文

• 痔瘻再発に関する要因 : 直腸肛門内圧検査および経肛門的超音波検査による検討
• 尾骨部嚢胞性疾患3手術症例の検討
• DP-054-7 直腸肛門周囲膿瘍の細菌培養検査と経肛門超音波検査は痔瘻化の有無を予測する(第107回日本外科学会定期学術集会)
• 肛門部尖圭コンジローマの外科切除後の再発の危険因子
• 痔瘻根治術後の肛門機能障害の危険因子と肛門内圧検査の意義
• エビデンスに基づいた直腸肛門周囲膿瘍・痔瘻の治療戦略
• 直腸に発生したサルコイドーシスの1例
• PS-197-4 肛門良性疾患術後の排尿障害における危険因子についての検討
• Synthesis of Antimicrobial Agents. VII. Synthesis and Antibacterial Activities of Furo [2,3-g] quinoline Derivatives
• Synthesis of Antimicrobial Agents. VI. Studies on the Synthesis of Furo [3,2-b] [1,8] naphthyridine Derivatives
• 22 香附子のセスキテルペノイドCyperoloneの構造
• Synthesis and Pharmacological Activities of Novel Bicyclic Thiazoline Derivatives as Hepatoprotective Agents. II. (7-Alkoxycarbonyl-2,3,5,6-tetrahydropyrrolo[2,1-b]thiazol-3-ylidene)acetamide Derivatives
• Synthesis and Pharmacological Activities of Novel Bicyclic Thiazoline Derivatives as Hepatoprotective Agents. I. 8-Ethoxycarbonyl-5,6-dihydrothiazolo[2,3-c][1,4]thiazine Derivatives
• 含フッ素ピリミジン系スルファニルアミド誘導体の合成と抗菌性
• HP-036-1 エビデンスに基づいた直腸肛門周囲膿瘍・痔瘻の治療戦略(肛門疾患,ハイブリッドポスター,第109回日本外科学会定期学術集会)
• 痔瘻の診断と分類 (特集 肛門疾患診療のすべて) -- (痔瘻)
• 痔核に対する外来手術の実際 : 有床施設における
• Synthesis and Antiallergy Activity of [1,3,4]Thiadiazolo[3,2-a]-1,2,3-triazolo[4,5-d]pyrimidin-9(3H)-one Derivatives. I
• The Metabolic Fate of 1-(4-Methoxy-6-methyl-2-pyrimidinyl)-3-methyl-5-methoxypyrazole (Mepirizole, DA-398) in Rats and Rabbits
• 化学療法薬の合成(第2報)1,8-Naphthyridine誘導体の合成と抗トリコモナス活性
• Analytical Studies on Mepirizole and Its Metabolites. III. Gas Chromatographic Determination of Mepirizole and Its Metabolites in Biological Fluids
• Synthesis and Antibacterial Activities of Optically Active Ofloxacin and Its Fluoromethyl Derivative(Medicinal Chemistry,Chemical)
• Synthesis of Antimicrobial Agents. IV. Synthesis and Antimicrobial Activities of Imidazo [4,5-b] [1,8] naphthyridine Derivatives
• Synthesis of Antimicrobial Agents. III. Synthesis and Antimicrobial Activities of Thiazolo [5,4-b] naphthyridine Derivatives
• Synthesis of Antimicrobial Agents. I. Synthesis and Antimicrobial Activities of Thiazoloquinoline Derivatives
• ナリジクス酸関連化合物研究の現況 (新しい医薬品の開発)
• Synthetic Chemotherapeutic Agents. IV. Synthesis of 3-Substituted Thiazolo [5,4-f] quinoline Derivatives. (2)
• Synthetic Chemotherapeutic Agents. III. Synthesis of 3-Substituted Thiazolo [5,4-f] quinoline Derivatives. (1)
• Synthetic Chemotherapeutic Agents. II. Synthesis of 2-Substituted Thiazolo [5,4-f] quinoline Derivatives. (2)
• Synthetic Chemotherapeutic Agents. I. Synthesis of 2-Substituted Thiazolo [5,4-f] quinoline Derivatives. (1)
• Syntheses of the Urinary Metabolites of 1-(4-Methoxy-6-methyl-2-pyrimidinyl)-3-methyl-5-methoxypyrazole (Mepirizole, DA-398)
• Synthesis of 1-Substituted 1,4-Dihydro-7-[2-(5-nitro-2-furyl) vinyl]-4-oxo-1,8-naphthyridine Derivatives. II
• Synthesis of 1-Substituted 1,4-Dihydro-7-[2-(5-nitro-2-furyl) vinyl]-4-oxo-1,8-naphthyridine Derivatives. I
• Synthesis and Antibacterial Activities of Substituted 7-Oxo-2,3-dihydro-7H-pyrido [1,2,3-de] [1,4] benzoxazine-6-carboxylic Acids
• Analytical Studies on Mepirizole and Its Metabolites. IV. Quantitative Determination of Mepirizole in Human Serum by Mass Fragmentography, and Isotope Effect on Drug Metabolism
• Analytical Studies on Mepirizole and Its Metabolites. II. Identification of the Human Urinary Metabolites of Mepirizole with Stable Isotope Labeling
• Analytical Studies on Mepirizole and Its Metabolites. : I. Mass Spectra of Mepirizole and Its Some Metabolites
• 坐骨直腸窩痔瘻に対する筋肉充填〓術の検討
• Synthesis of Antimicrobial Agents. V. Synthesis and Antimicrobial Activities of Some Heterocyclic Condensed 1,8-Naphthyridine Derivatives
• Structure and Absolute Configuration of Campherenone and Campherenol, Sesquiterpenoids of Cinnamomum camphora
• Structure and Absolute Configuration of Kusunol
• Synthesis of Cyperolone and 3-epi-Cyperolone.
• Synthesis of Cyperolone
• VII.肛門内圧からみた裂肛に対するLSISの適応と工夫
• 最近のキノロン系抗菌剤の探索
• 裂肛に対する側方皮下内括約筋切開術 (特集 肛門疾患治療の裏技,秘伝,奥義)
• 深部痔瘻における CT 検査の有用性と限界
• 経肛門的超音波検査による膿瘍の診断とガイド下穿刺生検について
• Evaluation of epidural buprenorphine and droperidol for postoperative analgesia in anal surgery.

もっと見る 閉じる

スポンサーリンク