Synthesis and Antibacterial Activities of Substituted 7-Oxo-2,3-dihydro-7H-pyrido [1,2,3-de] [1,4] benzoxazine-6-carboxylic Acids
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概要
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As part of a search for new synthetic antibacterial agents to combat systemic infection, various analogues of 7-oxo-2,3-dihydro-7H-pyrido [1,2,3-de] [1,4] benzoxazine-6-carboxylic acids were synthesized. Among the compounds newly synthesized, 9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido [1,2,3-de] [1,4] benzoxazine-6-carboxylic acid (DL-8280) showed potent antibacterial activity against Gram-positive and-negative pathogens, including Psedomonas aeruginosa, and its metabolic disposition was shown in separate experimentals to be favorable.
- 公益社団法人日本薬学会の論文
- 1984-12-25
著者
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田中 良明
Research Institute, Daiichi Seiyaku Co., Ltd.
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早川 勇夫
Research Institute, Daiichi Seiyaku Co., Ltd.
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田中 良明
Research Institute Daiichi Seiyaku Co. Ltd.
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早川 勇夫
第一製薬
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平光 時幸
Research Institute, Daiichi Seiyaku Co., Ltd.
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平光 時幸
Research Institute Daiichi Seiyaku Co. Ltd.
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