Analytical Studies on Mepirizole and Its Metabolites. II. Identification of the Human Urinary Metabolites of Mepirizole with Stable Isotope Labeling
スポンサーリンク
概要
- 論文の詳細を見る
The metabolism of mepirizole (I) in human urine was studied by labeling the drug with a stable isotope, deuterium. An equimolar mixture of the deuterium labeled mepirizole (II) and its protium counterpart (I) was administered orally to a man. The metabolites were extracted from the pooled urine with CH_2Cl_2,treated with diazomethane and applied to GC-MS. The ion clusters in the mass spectra were used for detection of the urinary metabolites of I in man. By this technique, three metabolites, 1-(4-methoxy-6-methyl-2-pyrimidinyl)-5-methoxy-3-hydroxymethylpyrazole (III), 1-(4-methoxy-6-methyl-2-pyrimidinyl)-5-methoxypyrazole-3-carboxylic acid (IV) and 1-(4-methoxy-6-carboxy-2-pyrimidinyl)-5-methoxy-3-methylpyrazole (V) were identified in human urine.
- 公益社団法人日本薬学会の論文
- 1976-04-25
著者
-
田中 良明
Research Institute, Daiichi Seiyaku Co., Ltd.
-
田中 良明
Research Institute Daiichi Seiyaku Co. Ltd.
-
佐野 光司
Research Institute, Daiichi Seiyaku Co., Ltd.
-
佐野 光司
Research Institute Daiichi Seiyaku Co. Ltd.
関連論文
- Synthesis of Antimicrobial Agents. VII. Synthesis and Antibacterial Activities of Furo [2,3-g] quinoline Derivatives
- Synthesis of Antimicrobial Agents. VI. Studies on the Synthesis of Furo [3,2-b] [1,8] naphthyridine Derivatives
- 含フッ素ピリミジン系スルファニルアミド誘導体の合成と抗菌性
- Studies on Pyrimidinylpyrazoles. III. Tautomerism of 1-and 2-Pyrimidinylpyrazolines
- The Application of Lanthanide Shift Reagent. I. Conformational Analysis of 1-[2-(1,3-Dimethyl-2-butenylidene) hydrazino]-phthalazine (DJ-1461) by Lanthanide Induced Shifts
- The Metabolic Fate of 1-(4-Methoxy-6-methyl-2-pyrimidinyl)-3-methyl-5-methoxypyrazole (Mepirizole, DA-398) in Rats and Rabbits
- Analytical Studies on Mepirizole and Its Metabolites. III. Gas Chromatographic Determination of Mepirizole and Its Metabolites in Biological Fluids
- Reaction Products of 1-Hydrazinophthalazine with Mesityl Oxide : X-Ray Structural Characterization
- Synthesis of Antimicrobial Agents. IV. Synthesis and Antimicrobial Activities of Imidazo [4,5-b] [1,8] naphthyridine Derivatives
- Synthesis of Antimicrobial Agents. I. Synthesis and Antimicrobial Activities of Thiazoloquinoline Derivatives
- ナリジクス酸関連化合物研究の現況 (新しい医薬品の開発)
- Syntheses of the Urinary Metabolites of 1-(4-Methoxy-6-methyl-2-pyrimidinyl)-3-methyl-5-methoxypyrazole (Mepirizole, DA-398)
- Synthesis of 1-Substituted 1,4-Dihydro-7-[2-(5-nitro-2-furyl) vinyl]-4-oxo-1,8-naphthyridine Derivatives. II
- Synthesis of 1-Substituted 1,4-Dihydro-7-[2-(5-nitro-2-furyl) vinyl]-4-oxo-1,8-naphthyridine Derivatives. I
- Synthesis and Antibacterial Activities of Substituted 7-Oxo-2,3-dihydro-7H-pyrido [1,2,3-de] [1,4] benzoxazine-6-carboxylic Acids
- Analytical Studies on Mepirizole and Its Metabolites. IV. Quantitative Determination of Mepirizole in Human Serum by Mass Fragmentography, and Isotope Effect on Drug Metabolism
- Analytical Studies on Mepirizole and Its Metabolites. II. Identification of the Human Urinary Metabolites of Mepirizole with Stable Isotope Labeling
- Analytical Studies on Mepirizole and Its Metabolites. : I. Mass Spectra of Mepirizole and Its Some Metabolites
- Metabolism of Budralazine, a New Antihypertensive Agent. II. Metabolic Pathways of Budralazine in Rats
- Metabolism of Methylscopolammonium Methylsulfate (DD-234) in Rats
- Metabolites of DJ-1461 in Rat Urine
- Studies on Nucleosides and Nucleotides. V. Ultraviolet Spectrophotometric Studies on Pyrimidine Nucleosides and Isopyrimidine Nucleosides.
- Studies on Nucleosides and Nucleotides. IV. Synthesis of Isoglycosyluracils and Isoglycosyl-2-thiouracils from Glycosylureas and Glycosylthioureas.
- Studies on Nucleosides and Nucleotides. III. Synthesis of Glycosy1-2-thiouracils from Glycosylthioureas.
- Studies on Nucleosides and Nucleotides. II. Synthesis of Glycosyl-2-thiothymines from Glycosylthioureas.
- Studies on Nucleosides and Nucleotides. I. Synthesis of Glycosylthymines from Glycosylureas.
- A New Synthetic Method for Pyrimidine Nucleoside