Studies on Nucleosides and Nucleotides. III. Synthesis of Glycosy1-2-thiouracils from Glycosylthioureas.
スポンサーリンク
概要
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Synthesis of glycosylthiouracil from glycosylthiourea was carried out by the method for synthesis of glycosylthymine described in Part II of this series. 1-Methyl-3-(3-ethoxyacryloyl) thiourea, obtained from N-methylthiourea and ethyl 3,3-diethoxyacryloyl chloride, was submitted to pyrimidine cyclization and 1-methyl-2-thiouracil was found to be produced. In accordance with this model experiment, 1-(β-D-glucopyranosyl)-2-thiouracil was obtained from 1-(tetra-O-acetyl-β-D-glucopyranosyl) thiourea and ethyl 3,3-diethoxyacryloyl chloride, and 1-(β-D-ribofuranosyl)-2-thiouracil (2-thiouridine) from 1-(tri-O-benzoyl-β-D-ribofuranosyl) thiourea.
- 公益社団法人日本薬学会の論文
- 1962-04-25
著者
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佐野 光司
Research Institute, Daiichi Seiyaku Co., Ltd.
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佐野 光司
Research Institute Daiichi Seiyaku Co. Ltd.
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