The Application of Lanthanide Shift Reagent. I. Conformational Analysis of 1-[2-(1,3-Dimethyl-2-butenylidene) hydrazino]-phthalazine (DJ-1461) by Lanthanide Induced Shifts
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概要
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The structure of DJ-1461 in solution was determined by using lanthanide shift reagents. The position of the lanthanide ion and the protons of DJ-1461 in the complex were determined using the McConnell-Robertson equation. The shifts induced by lanthanide shift reagents agreed well with the calculated values, on the assumption that their origin is of pseudocontact nature. The europium ion-N^2 bond length was as long as 3.2 Å (phthalazine N^2 is set at the origin of the right handed polar co-ordinates system). It was found that the side chain of the DJ-1461 has an anti form towards the C=N bond, and the two double bonds S-cis configuration.
- 公益社団法人日本薬学会の論文
- 1976-10-25
著者
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諸井 黎明
Research Institute, Daiichi Seiyaku Co., Ltd.
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富田 真雄
Research Institute Daiichi Seiyaku Co. Ltd.
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佐野 光司
Research Institute, Daiichi Seiyaku Co., Ltd.
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佐野 光司
Research Institute Daiichi Seiyaku Co. Ltd.
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諸井 黎明
Developmental Research Laboratories Daiichi Pharmaceutical Co. Ltd.
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Moroi R
Developmental Research Laboratories Daiichi Pharmaceutical Co. Ltd.
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