Metabolism of Methylscopolammonium Methylsulfate (DD-234) in Rats
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概要
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The metabolism of methylscopolammonium methylsulfate (I) in rats was investigated. Eight metabolites were detected in urine and faeces after oral and subcutaneous administrations. The feature of metabolic pathway was characterized as follows ; i) the quarternary ammonium moiety was unchanged, ii) major pathway involved oxidation at the paraposition of benzene ring to introduce a hydroxy and a methoxy groups, iii) minor products were the apo-derivative, glucuronide of I and scopine derivative. Absorption and excretion were examined by using ^<14>C-labeled compound, and excreted total radioactivities were 82.2% of oral dose and 93.6% of subcutaneous dose in urine and faeces. In respiratory air ^<14>CO_2 was not detectable. Comparison of the metabolic pathway with that of tertiary scopolamine are also discussed.
- 公益社団法人日本薬学会の論文
- 1974-03-25
著者
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Hakusui H
Daiichi Pharmaceutical Co. Ltd. Tokyo Jpn
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伯水 英夫
Developmental Research Laboratories Daiichi Pharmaceutical Co. Ltd.
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佐野 光司
Research Institute, Daiichi Seiyaku Co., Ltd.
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佐野 光司
Research Institute Daiichi Seiyaku Co. Ltd.
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伯水 英夫
Research Institute, Daiichi Seiyaku Co., Ltd.
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