Studies on Nucleosides and Nucleotides. I. Synthesis of Glycosylthymines from Glycosylureas.
スポンサーリンク
概要
- 論文の詳細を見る
As a new method for synthesis of pyrimidine nucleoside, synthesis of glycosylthymine from glycosylurea was carried out. As a model experiment, pyrimidine cyclization was examined with N-methylurea and N-methylthiourea with methyl 2-methyl-3-methoxyacrylate, 2-methyl-3-methoxyacryloyl chloride, and ethyl β-formylpropionate. Starting from 1-D-glucosylurea and 1-D-arabinosylurea, protecting the hydroxyls in the sugar portion by acetylation, condensation with 2-methyl-3-methoxyacryloyl chloride afforded the intermediates, (XI) and (XV), and their cyclization successfully produced 1-β-D-glucopyranosylthymine and 1-D-arabinosylthymine.
- 公益社団法人日本薬学会の論文
- 1961-09-25
著者
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佐野 光司
Central Research Laboratory, Daiichi Seiyaku Co., Ltd.
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内藤 武男
Central Research Laboratory, Daiichi Seiyaku Co., Ltd.
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佐野 光司
Research Institute, Daiichi Seiyaku Co., Ltd.
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平田 三四司
Research Institute, Daiichi Seiyaku Co., Ltd.
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平田 三四司
Research Institute Daiichi Seiyaku Co. Ltd.
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佐野 光司
Research Institute Daiichi Seiyaku Co. Ltd.
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平田 三四司
Central Research Laboratory Daiichi Seiyaku Co. Ltd.
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川上 知吉
Central Research Laboratory, Daiichi Seiyaku Co., Ltd.
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川上 知吉
Central Research Laboratory Daiichi Seiyaku Co. Ltd.
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