N^1-(5-ハロゲノピリミジニル)スルファニルアミド誘導体の合成

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概要

• 論文の詳細を見る

• A series of 5-halogenopyrimidinylsulfanilamides (I), possessing methyl, alkoxy, and/or alkylthio groups in the pyrimidine ring, were prepared from the corresponding N^4-acetyl derivatives (II) by alkaline hydrolysis. Most of II were prepared from N^4-acetyl-pyrimidinylsulfanilamide derivatives by halogenation with NBS or NCS, and the effect of substituents in the pyrimidine ring upon the halogenation reaction was clarified.

• 公益社団法人日本薬学会の論文
• 1972-03-25

著者

• 平田 三四司

  第一製薬株式会社中央研究所

• 磯田 純郎

  第一製薬株式会社中央研究所

• 金尾 宗史

  Research Institute, Daiichi Seiyaku Co., Ltd.

• 磯田 純郎

  Research Institute Daiichi Seiyaku Co. Ltd.

• 平田 三四司

  Research Institute, Daiichi Seiyaku Co., Ltd.

• 平田 三四司

  Research Institute Daiichi Seiyaku Co. Ltd.

• 金尾 宗史

  第一製薬株式会社総合研究所

• 清水 弘也

  第一製薬株式会社総合研究所

• 金尾 宗史

  Research Institute Daiichi Seiyaku Co. Ltd.

関連論文

• ピリミジン系スルファニルアミド誘導体の合成と抗菌性
• Studies on Nucleosides and Nucleotides. VIII. Nucleophilic Substitution of Secondary Sulfonyloxy Groups of Pyrimidine Nucleosides. (1)
• The Nucleophilic Substitution of Secondary Sulfonyloxy Groups of Pyrimidine Nucleosides
• A Reagent, Ethyl 2-(2-tert-Butyl-2H-tetrazol-5-yl)-3-(dimethylamino)acrylate (DMTE), for Facile Synthesis of 2,3-(Ring Fused)-5-(5-tetratzolyl)-4H-pyrimidin-4-one Derivatives
• Studies on α_2-Plasmin Inhibitor Fragment T-11. III. Structure-Activity Relationships among the Fragments of T-11, the Plasminogen Binding Site(s) of Human α_2-Plasmin Inhibitor(Medicinal Chemistry,Chemical)
• Studies on α_2-Plasmin Inhibitor Fragment T-11. II. Synthesis of the Entire Amino Acid Sequence of α_2-Plasmin Inhibitor Fragment T-11(Medicinal Chemistry,Chemical)
• Studies on α_2-Piasmin Inhibitor Fragment T-11. I. Synthesis of the Protected Hexadecapeptide Ester Corresponding to Positions 11 through 26 of α_2-Plasmin Inhibitor Fragment T-11(Medicinal Chemistry,Chemical)
• Spasmolytic Agents. I. Aminoalcohol Esters having a Phenethylamine-Like Moiety
• Medicinal Chemical Studies on Antiplasmin Drugs. VIII. 4-Aminomethylcyclohexanecarboxylic Acid Derivatives having a Carboxyl or Carboxymethyl Group at C_2
• Medicinal Chemical Studies on Antiplasmin Drugs. V. 4-Aminomethylcyclohexanecarboxylic Acid Derivatives having a Methyl Group at C_2 or C_3
• Studies on Nucleosides and Nucleotides. XII. Syntheses of 3'-Amino-3'-deoxypentofuranosylcytosines
• ポリアミドクロマトグラフィーの研究(第2報) : 数種のフェノール性物質分離へのポリアミドカラムクロマトグラフィーの応用
• Medicinal Chemical Studies on Antiplasmin Drugs. VII. Oxa Analogs of 4-Aminomethylcyclohexanecarboxylic Acid
• Medicinal Chemical Studies on Antiplasmin Drugs. VI. Aza Analogs of 4-Aminomethylbenzoic Acid
• Medicinal Chemical Studies on Antiplasmin Drugs. III. 4-Aminomethylcyclohexanecarboxylic Acid and Its Derivatives having a Methyl Group
• N^1-(5-ハロゲノピリミジニル)スルファニルアミド誘導体の合成
• Synthesis of 3-Pyridinols. I. Reaction of 5-Unsubstituted Oxazoles with Acrylonitrile
• Studies on Nucleosides and Nucleotides. I. Synthesis of Glycosylthymines from Glycosylureas.
• A New Synthetic Method for Pyrimidine Nucleoside
• 魚類麻酔薬の合成研究

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