Studies on α_2-Plasmin Inhibitor Fragment T-11. II. Synthesis of the Entire Amino Acid Sequence of α_2-Plasmin Inhibitor Fragment T-11(Medicinal Chemistry,Chemical)
スポンサーリンク
概要
- 論文の詳細を見る
The hexacosapeptide corresponding to the entire amino acid sequence of human α_2-plasmin inhibitor fragment T-11 was synthesized by a conventional solution method. Three newly synthesized fragments were combined successively with the protected C-terminal hexadecapeptide ester previously obtained by using the dicyclohexylcarbodiimide-N-hydroxybenzotriazole and azide procedures to afford the protected hexacosapeptide ester. The trifluoromethanesulfonic acidthioanisole-trifluoroacetic acid procedure was employed to remove all protecting groups of the protected peptide ester at the final stage. The dissociation constant for the interaction between the synthetic α_2-plasmin inhibitor fragment T-11 and plasmin was equal to that of the native T-11 from human α_2-plasmin inhibitor.
- 公益社団法人日本薬学会の論文
- 1987-07-25
著者
-
磯田 純郎
Exploratory Research Laboratories Iii Daiichi Pharmaceutical Co. Ltd.
-
佐々木 敬
Research Institute Daiichi Seiyaku Co. Ltd.
-
磯田 純郎
Research Institute, Daiichi Pharmaceutical Co., Ltd.,
-
磯田 純郎
Research Institute Daiichi Seiyaku Co. Ltd.
関連論文
- Studies on Peptides. LXXIX. : By-Products derived from N^α-Protected Tryptophan by Acids
- Studies on Peptides. LXXVI. Synthesis of Kassinin, a New Frog Skin Peptide
- ピリミジン系スルファニルアミド誘導体の合成と抗菌性
- Synthesis and Antiallergy Activity of [1,3,4]Thiadiazolo[3,2-α]-1,2,3-triazolo[4,5-d]pyrimidin-9(3H)-one Derivatives. II. 6-Alkyl- and 6-Cycloalkylalkyl Derivatives
- Synthesis and Antiallergy Activity of [1,3,4]Thiadiazolo[3,2-a]-1,2,3-triazolo[4,5-d]pyrimidin-9(3H)-one Derivatives. I
- A Reagent, Ethyl 2-(2-tert-Butyl-2H-tetrazol-5-yl)-3-(dimethylamino)acrylate (DMTE), for Facile Synthesis of 2,3-(Ring Fused)-5-(5-tetratzolyl)-4H-pyrimidin-4-one Derivatives
- Studies on α_2-Plasmin Inhibitor Fragment T-11. III. Structure-Activity Relationships among the Fragments of T-11, the Plasminogen Binding Site(s) of Human α_2-Plasmin Inhibitor(Medicinal Chemistry,Chemical)
- Studies on α_2-Plasmin Inhibitor Fragment T-11. II. Synthesis of the Entire Amino Acid Sequence of α_2-Plasmin Inhibitor Fragment T-11(Medicinal Chemistry,Chemical)
- Studies on α_2-Piasmin Inhibitor Fragment T-11. I. Synthesis of the Protected Hexadecapeptide Ester Corresponding to Positions 11 through 26 of α_2-Plasmin Inhibitor Fragment T-11(Medicinal Chemistry,Chemical)
- Spasmolytic Agents. I. Aminoalcohol Esters having a Phenethylamine-Like Moiety
- Medicinal Chemical Studies on Antiplasmin Drugs. VIII. 4-Aminomethylcyclohexanecarboxylic Acid Derivatives having a Carboxyl or Carboxymethyl Group at C_2
- Medicinal Chemical Studies on Antiplasmin Drugs. V. 4-Aminomethylcyclohexanecarboxylic Acid Derivatives having a Methyl Group at C_2 or C_3
- Studies on Peptides. LXXIV. Convenient Procedure for the Preparation of Methionine Sulphoxide Derivatives
- Studies on Peptides. LXXII. Examination of the N^ε-Alkylation of Lysine in the Methanesulphonic Acid Procedure for Peptide Synthesis
- Medicinal Chemical Studies on Antiplasmin Drugs. VII. Oxa Analogs of 4-Aminomethylcyclohexanecarboxylic Acid
- Medicinal Chemical Studies on Antiplasmin Drugs. VI. Aza Analogs of 4-Aminomethylbenzoic Acid
- Medicinal Chemical Studies on Antiplasmin Drugs. III. 4-Aminomethylcyclohexanecarboxylic Acid and Its Derivatives having a Methyl Group
- N^1-(5-ハロゲノピリミジニル)スルファニルアミド誘導体の合成
- Synthesis of 3-Pyridinols. I. Reaction of 5-Unsubstituted Oxazoles with Acrylonitrile