Spasmolytic Agents. I. Aminoalcohol Esters having a Phenethylamine-Like Moiety
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概要
- 論文の詳細を見る
A series of semi-rigid analogs of phenethylamine was prepared as fixed transoid and cisoid analogs of mebeverine, and tested for spasmolytic activity in vitro. The fixed transoid analogs were more potent than the corresponding cisoid analogs. In this series, tetrahydro-2-napthylamine derivative (2a) which is presumed to take transoid conformation had the most potent activity, and tetrahydroisoquinoline derivatives (2g and 2h) which are presumed to take typical cisoid conformations were less active. These results suggested that the phenethylamine moiety of mebeverine takes the transoid conformation for the manifestation of the spasmolytic activity.
- 公益社団法人日本薬学会の論文
- 1982-01-25
著者
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橋爪 武司
Research Laboratories, Daiichi Seiyaku Co., Ltd.
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磯田 純郎
Exploratory Research Laboratories Iii Daiichi Pharmaceutical Co. Ltd.
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市川 喜文
Research Institute, Daiichi Pharmaceutical Co., Ltd.,
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磯田 純郎
Research Institute, Daiichi Pharmaceutical Co., Ltd.,
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金尾 宗史
Research Institute, Daiichi Seiyaku Co., Ltd.
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入江 清
Research Institute, Daiichi Seiyaku Co., Ltd.
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佐藤 嘉生
Research Institute, Daiichi Seiyaku Co., Ltd.
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入江 清
Research Institute Daiichi Seiyaku Co. Ltd.
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磯田 純郎
Research Institute Daiichi Seiyaku Co. Ltd.
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佐藤 嘉生
Research Institute Daiichi Seiyaku Co. Ltd.
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橋爪 武司
Research Institute Daiichi Seiyaku Co. Ltd.
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金尾 宗史
Research Institute Daiichi Seiyaku Co. Ltd.
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市川 喜文
Research Institute Daiichi Pharmaceutical Co. Ltd.
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