Some Non-hormonal Properties of 17β-Hydroxy-17α-methyl-5α-androstano[2,3-c]furazan (Furazabol)
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概要
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Furazabol showed non-specific inhibitory activities to the responses of guinea pig ileum to various spasmogens, and the activities were considerably higher than those of papaverine. It inhibited also the response of guinea pig vas deferens to adrenaline, depressed spontaneous movements of guinea pig atria and rat uterus and showed a slight and temporal fall in blood pressure which was not affected by the pretreatment of atropine. These data suggest that furazabol has a papaverine-like property. Furazabol showed serum cholesterol-lowering action in normal rats and cholesterol-fed chicks. In addition, it exerted curative action on gastric stress ulcer in rats.
- 社団法人日本薬学会の論文
- 1973-01-25
著者
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笠原 明
Research Laboratories Daiichi Seiyaku Co. Ltd.
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小野寺 威
Research Laboratories, Daiichi Seiyaku Co., Ltd.
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橋爪 武司
Research Laboratories, Daiichi Seiyaku Co., Ltd.
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小野寺 威
Research Laboratories Daiichi Seiyaku Co. Ltd.
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橋爪 武司
Research Institute Daiichi Seiyaku Co. Ltd.
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