Investigations on Steroids. IX. Pharmacological Studies. (3). Myotrophic and Androgenic Activities of 17β-Hydroxy-5α-androstano-[2,3-c] furazan and Its Derivatives

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概要

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• 17β-Hydroxy-5α-androstano [2,3-c] furazan (I) has been shown to possess a high myotrophic activity and a low androgenic activity by subcutaneous injection, but its activities by oral route are very low. On the other hand, when given orally, 17-(2-tetrahydropyranyl) and 17-(1-cyclopentenyl) ethers of I are highly myotrophic and have shown a good separation of myotrophic and androgenic activities. The myotrophic and androgenic activities of 17α-ethyl, vinyl, ethynyl, 16-methylene, 16β-methyl, 16α-, and 16β-hydroxy derivatives of I are less than those of I.

• 社団法人日本薬学会の論文
• 1968-08-25

著者

• 笠原 明

  Research Laboratories Daiichi Seiyaku Co. Ltd.

• 笠原 明

  Central Research Laboratory Daiichi Seiyaku Co. Ltd.

• 小野寺 威

  Central Research Laboratory, Daiichi Seiyaku Co., Ltd.

• 大島 康夫

  Central Research Laboratory, Daiichi Seiyaku Co., Ltd.

• 清水 正夫

  Central Research Laboratory, Daiichi Seiyaku Co., Ltd.

• 大島 康夫

  Biological Research Laboratory Research Laboratories Daiichi Seiyaku Co. Ltd.

• 清水 正夫

  Central Research Laboratory Daiichi Seiyaku Co. Ltd.

• 小野寺 威

  Research Laboratories Daiichi Seiyaku Co. Ltd.

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