Medicinal Chemical Studies on Antiplasmin Drugs. I. Establishment of the Screening Assay Method for Antiplasmin Drugs and the Superiority of trans-4-Aminomethylcyclohexanecarboxylic Acid (Tranexamic Acid) to cis-Form

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概要

• 論文の詳細を見る

• The new caseinolytic assay method for antiplasmin activity of synthetic compounds was established by introducing the determination of ID_50. trans-Form isomer of 4-aminomethylcyclohexanecarboxylic acid (tranexamic acid) was shown to have very potent antiplasmin activity whereas the cis-form isomer was little effective. The antiplasmin activity of tranexamic acid was 5-7 times greater than that of ε-aminocaproic acid.

• 公益社団法人日本薬学会の論文
• 1968-02-25

著者

• 清水 正夫

  Central Research Laboratory, Daiichi Seiyaku Co., Ltd.

• 岡野 淳二

  Central Research Laboratory Daiichi Seiyaku Co. Ltd.

• 内藤 武男

  Central Research Laboratory, Daiichi Seiyaku Co., Ltd.

• 安孫子 雍史

  第一製薬総合研究所

• 安孫子 雍史

  Central Research Laboratory, Daiichi Seiyaku Co., Ltd.

• 清水 正夫

  Central Research Laboratory Daiichi Seiyaku Co. Ltd.

• 内藤 武男

  Research Laboratories, Daiichi Seiyaku Co., Ltd.

• 青柳 高明

  Central Research Laboratory, Daiichi Seiyaku Co., Ltd.

• 岩本 政博

  Central Research Laboratory, Daiichi Seiyaku Co., Ltd.

• 岩本 雅博

  Research Institute Daiichi Seiyaku Co. Ltd.

• 岩本 政博

  Research Institute Daiichi Seiyaku Co.. Ltd.

• 内藤 武男

  Research Laboratories Daiichi Seiyaku Co. Ltd.

• 青柳 高明

  Showa College Of Pharmaceutical Sciences

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