Studies on the Constituents of Digitalis purpurea L. VIII. The Isolation of Neogitostin, a New Cardiotonic Glycoside.
スポンサーリンク
概要
- 論文の詳細を見る
Of the 17 kinds of unknown cardiotonic glycoside-like substances contained in the seeds of Digitalis purpurea, described in Part II of this series, a glycoside corresponding to substance A-IX was isolated. This substance was not obtained in crystalline form, but by the usual deacetylation of its acetate, monoacetate came as needle crytals of m.p. 249〜252° (Kofler, uncorr.) ; [α]^<24>_D-14.2°±3° ; C_<44>H_<68>O_<20>・H_2O ; negative to Keller-Kiliani reaction, giving carmine red sulfuric acid layer, and positive to Legal and Raymond reactions ; U.V. λ^<EtOH>_<max>218mμ (log ε 4.18). These results indicated the substance to be a cardiotonic glycoside. Its hydrolysis with 3.5% hydrochloric acid afforded dianhydrogitoxigenin and the sugar portion was found to be digitalose and glucose by paper partition chromatography. Determination of glucose showed the presence of two moles. Therefore this substance was found to be a new glycoside, an isomer of gitostin which was reported in Part III, and was named neogitostin. Gitostin monoacetate was prepared and compared with neogitostin monoacetate. By paper chromatography for strong polar glycoside portion, a new spot was confirmed between the spots of gitostin and neogitostin, and numbered A-VIII'.
- 公益社団法人日本薬学会の論文
- 1958-04-20
著者
-
岡野 淳二
Central Research Laboratory Daiichi Seiyaku Co. Ltd.
-
岡野 淳二
Research Laboratory, Daiichi Seiyaku Co., Ltd.
関連論文
- Medicinal Chemical Studies on Antiplasmin Drugs. II. Separation of Stereoisomers of 4-Aminomethylcyclohexanecarboxylic Acid and Assignment of Their Configuration
- Medicinal Chemical Studies on Antiplasmin Drugs. I. Establishment of the Screening Assay Method for Antiplasmin Drugs and the Superiority of trans-4-Aminomethylcyclohexanecarboxylic Acid (Tranexamic Acid) to cis-Form
- trans-4-Aminomethylcyclohexanecarboxylic Acid as a Potent Antiplasmin Agent
- Studies on the Constituents of Digitalis purpurea L. XXIII. On the 16-Formyl Derivative of Digitalinum Verum.
- Studies on the Constituents of Digitalis purpurea L. XXII. Alloneogitostin, a New Glycoside from Digitalis Seeds.
- Studies on the Constituents of Digitalis purpurea L. XXI. Allo-digitalinum verum, a New Glycoside from Digitalis Seeds.
- Studies on the Constituents of Digitalis purpurea L. XVII. Isolation of Several New Glycosides from Fraction PGB of Digitalis Seeds.
- 16-Acetylgitoxin, a New Derivative of Gitoxin
- Studies on the Constituents of Digitalis pur purea L. XVI. : On the Synthesis of 16-Acetyl-strospeside.
- Studies on the Constituents of Digitalis purpurea L. XIV. 16-Acetyl and 16-Propionyl Derivatives of Digitalinum Verum.
- Studies on the Constituents of Digitalis purpurea L. XIII. On the Diacyl Derivatives of Digitalinum Verum.
- Studies on the Constituents of Digitalis purpurea L. XII. New Cardiotonic Glycosides, Gitorocellobioside, Glucogitoroside, and Gitoxin-cellobioside.
- Studies on the Constituents of Digitalis purpurea L. XI. Digifucocellobioside, a New Cardiotonic Glycoside from Digitalis Seeds.
- Studies on the Constitutents of Digitalis purpurea L. X. Isolation of Several New Glycosides from the Water-soluble Fraction of Digitalis Seeds.
- Studies on the Constituents of Digitalis purpurea L. IX. The Structures of Gitostin and Neogitostin.
- Studies on the Constituents of Digitalis purpurea L. VIII. The Isolation of Neogitostin, a New Cardiotonic Glycoside.
- 9.ジギタリスの新強心配糖体
- Studies on the Constituents of Digitalis purpurea L. V. On the Acetates of Some Cardiotonic Glycosides.
- Studies on the Constituents of Digitalis purpurea L. IV. Enzymatic Decomposition of Gitostin.
- Studies on the Constituents of Digitalis purpurea L. III. Gitostin, a New Cardiotonic Glycoside from Digitalis Seeds.
- Studies on the Constituents of Digitalis purpurea L. II. Paper Partition Chromatography of Cardioglycosides from Digitalis Seeds.