Studies on the Constituents of Digitalis purpurea L. IX. The Structures of Gitostin and Neogitostin.
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概要
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The structure of neogitostin, newly isolated from digitalis seeds by the writer and described in the preceding paper, was examined by enzymatic decomposition using the same enzyme isolated from a snail (Euhadra quaesita DESHAYES) as described in Part IV of this series. It was found that hydrolysis of amorphous neogitostin afforded strospeside and digitalinum verum. However, hydrolysis of monoacetates of gitostin and neogitostin, under the same conditions as those used in the partial decomposition of gitostin to form digitalinum verum but by shortening the duration of hydrolysis, glucose alone was found to be hydrolyzed from these monoacetates, affording digitalinum verum monoacetate. From these results, it was found that gitostin and neogitostin are isomeric triglycosides whose terminal glucose is linked to the terminal glucose in digitalinum verum. By respective acetolysis of gitostin nonaacetate and neogitostin nonaacetate, it was established that gitostin is gitoxigenin-β-cellobiosido-β-D-digitaloside and neogitostin is gitoxigenin-β-gentiobiosido-β-D-digitaloside.
- 公益社団法人日本薬学会の論文
- 1958-04-20
著者
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岡野 淳二
Central Research Laboratory Daiichi Seiyaku Co. Ltd.
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岡野 淳二
Research Laboratory, Daiichi Seiyaku Co., Ltd.
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- trans-4-Aminomethylcyclohexanecarboxylic Acid as a Potent Antiplasmin Agent
- Studies on the Constituents of Digitalis purpurea L. XXIII. On the 16-Formyl Derivative of Digitalinum Verum.
- Studies on the Constituents of Digitalis purpurea L. XXII. Alloneogitostin, a New Glycoside from Digitalis Seeds.
- Studies on the Constituents of Digitalis purpurea L. XXI. Allo-digitalinum verum, a New Glycoside from Digitalis Seeds.
- Studies on the Constituents of Digitalis purpurea L. XVII. Isolation of Several New Glycosides from Fraction PGB of Digitalis Seeds.
- 16-Acetylgitoxin, a New Derivative of Gitoxin
- Studies on the Constituents of Digitalis pur purea L. XVI. : On the Synthesis of 16-Acetyl-strospeside.
- Studies on the Constituents of Digitalis purpurea L. XIV. 16-Acetyl and 16-Propionyl Derivatives of Digitalinum Verum.
- Studies on the Constituents of Digitalis purpurea L. XIII. On the Diacyl Derivatives of Digitalinum Verum.
- Studies on the Constituents of Digitalis purpurea L. XII. New Cardiotonic Glycosides, Gitorocellobioside, Glucogitoroside, and Gitoxin-cellobioside.
- Studies on the Constituents of Digitalis purpurea L. XI. Digifucocellobioside, a New Cardiotonic Glycoside from Digitalis Seeds.
- Studies on the Constitutents of Digitalis purpurea L. X. Isolation of Several New Glycosides from the Water-soluble Fraction of Digitalis Seeds.
- Studies on the Constituents of Digitalis purpurea L. IX. The Structures of Gitostin and Neogitostin.
- Studies on the Constituents of Digitalis purpurea L. VIII. The Isolation of Neogitostin, a New Cardiotonic Glycoside.
- 9.ジギタリスの新強心配糖体
- Studies on the Constituents of Digitalis purpurea L. V. On the Acetates of Some Cardiotonic Glycosides.
- Studies on the Constituents of Digitalis purpurea L. IV. Enzymatic Decomposition of Gitostin.
- Studies on the Constituents of Digitalis purpurea L. III. Gitostin, a New Cardiotonic Glycoside from Digitalis Seeds.
- Studies on the Constituents of Digitalis purpurea L. II. Paper Partition Chromatography of Cardioglycosides from Digitalis Seeds.