Studies on the Constituents of Digitalis purpurea L. IV. Enzymatic Decomposition of Gitostin.
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概要
- 論文の詳細を見る
Gitostin, a new cardiotonic glycoside isolated from the seeds of Digitalis purpurea, was hydrolyzed with digestive enzyme from the intestine of a snail (Euhadra quaesita DESHAYES) and strospeside was obtained, confirming the structure of gitostin as gitoxigenin-glucosido-glucosido-digitaloside. Partial decomposition of gitostin with the same enzyme afforded digitalinum verum, indicating that this enzyme effected stepwise hydrolysis, liberating one mole each of glucose. From the fact that only digitalinum verum is obtained from gitostin, the extra glucose was found to be bonded to the glucose in digitalinum verum, and by the comparison of molecular rotation of gitostin and digitalinum verum, the bonding of this glucosylglucoside was confirmed to be in β-position to the terminal glucose.
- 公益社団法人日本薬学会の論文
- 1957-04-20
著者
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岡野 淳二
Central Research Laboratory Daiichi Seiyaku Co. Ltd.
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三木 藤作
Exploratory Research Laboratories III, Daiichi Pharmaceutical Co., Ltd.,
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岡野 淳二
Yanagishima Research Laboratory, Daiichi Seiyaku Co., Ltd.
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傍士 和彦
Yanagishima Research Laboratory, Daiichi Seiyaku Co., Ltd.
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三木 藤作
Yanagishima Research Laboratory, Daiichi Seiyaku Co., Ltd.
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宮武 一夫
Yanagishima Research Laboratory, Daiichi Seiyaku Co., Ltd.
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宮武 一夫
Research Laboratory Daiichi Seiyaku Co. Ltd.
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三木 藤作
Exploratory Research Laboratories Iii Daiichi Pharmaceutical Co. Ltd.
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岡野 淳二
Yanagishima Research Laboratory Daiichi Seiyaku Co. Ltd.
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傍士 和彦
第一製薬株式会社
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