Studies on the Constituents of Digitalis purpurea L. V. On the Acetates of Some Cardiotonic Glycosides.
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概要
- 論文の詳細を見る
Stoll has recently succeeded in crystallizing purpurea glycoside-A and -B, the true glycosides of Digitalis purpurea, but crystallization of these glycosides is generally difficult. Therefore, attempts were made to derive these glycosides to crystalline acetates and feasibility of their identification through these acetates was examined. As a result, the foregoing two glycosides and gitoxin were obtained as crystalline acetates and their melting points, optical rotation, coloration reaction, and paper partition chromatography have been described, together with those of the acetates of known digitalis glycosides and various aglycone acetates. Oral administration of gitoxin acetate and purpurea glycoside-B acetate showed them to be more toxic than their respective glycosides and their lethal dose in rats was found to have been much lowered.
- 公益社団法人日本薬学会の論文
- 1957-04-20
著者
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岡野 淳二
Central Research Laboratory Daiichi Seiyaku Co. Ltd.
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三木 藤作
Exploratory Research Laboratories III, Daiichi Pharmaceutical Co., Ltd.,
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岡野 淳二
Yanagishima Research Laboratory, Daiichi Seiyaku Co., Ltd.
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傍士 和彦
Yanagishima Research Laboratory, Daiichi Seiyaku Co., Ltd.
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三木 藤作
Yanagishima Research Laboratory, Daiichi Seiyaku Co., Ltd.
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宮武 一夫
Yanagishima Research Laboratory, Daiichi Seiyaku Co., Ltd.
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宮武 一夫
Research Laboratory Daiichi Seiyaku Co. Ltd.
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三木 藤作
Exploratory Research Laboratories Iii Daiichi Pharmaceutical Co. Ltd.
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岡野 淳二
Yanagishima Research Laboratory Daiichi Seiyaku Co. Ltd.
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傍士 和彦
第一製薬株式会社
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