Studies on the Constituents of Digitalis purpurea L. VI. Glucodigifucoside, a New Cardiotonic Glycoside.

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概要

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• Of the 17 kinds of unknown cardiotonic glycoside-like substance contained in the seeds of Digitalis purpurea, described in Part II of this series, a glycoside corresponding to substance C-I was isolated. This substance had a bitter taste and came as needle crystals of m. p. 194〜197°(Kofler, uncorr.) ; [α]^<21>_D+1.9±2° ; C_<35>H_<54>O_<13>・2H_2O ; negative to Keller-Kiliani reaction, giving brown sulfuric acid layer, and positive to Legal and Raymond reactions ; U.V. λ^<EtOH>_<max> 217mμ (log ε 4.23). These results indicated the substance to be a cardiotonic glycoside. Hydrolysis by the Mannich method afforded β-anhydrodigitoxigenin and digitoxigenin, and the sugar portion was identified as fucose and glucose by paper chromatography. Determination of glucose by the Borel-Hostettler-Deuel method, as in the case of gitostin, indicated the presence of 1 mole. Confirming this substance to be diglycoside, a new cardiotonic glycoside of digitoxigenin series, it was named glucodigifucoside.

• 公益社団法人日本薬学会の論文

著者

• 岡野 淳二

  Yanagishima Research Laboratory, Daiichi Seiyaku Co., Ltd.

• 岡野 淳二

  Yanagishima Research Laboratory Daiichi Seiyaku Co. Ltd.

関連論文

• Studies on the Constituents of Digitalis purpurea L. V. On the Acetates of Some Cardiotonic Glycosides.
• Studies on the Constituents of Digitalis purpurea L. IV. Enzymatic Decomposition of Gitostin.
• Studies on the Constituents of Digitalis purpurea L. III. Gitostin, a New Cardiotonic Glycoside from Digitalis Seeds.
• Studies on the Constituents of Digitalis purpurea L. II. Paper Partition Chromatography of Cardioglycosides from Digitalis Seeds.
• Studies on the Constituents of Digitalis purpurea L. VII. Enzymatic Decomposition of Glucodigifucoside.
• Studies on the Constituents of Digitalis purpurea L. VI. Glucodigifucoside, a New Cardiotonic Glycoside.

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