Studies on the Constituents of Digitalis purpurea L. XII. New Cardiotonic Glycosides, Gitorocellobioside, Glucogitoroside, and Gitoxin-cellobioside.
スポンサーリンク
概要
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The structures of substance B-III and B-III', newly isolated from digitalis seeds, were examined. It was found that enzymatic hydrolysis of substance B-III afforded gitoroside, and a mild acid hydrolysis afforded gitoxigenin and new trisaccharide which consists of cellobiose and digitoxose. This sugar was named digilanidotriose. Therefore, substance B-III is formulated as gitoxigenin cellobiosido-digitoxoside, and was designated as gitorocellobioside. The partial decomposition of gitorocellobioside with a snail enzyme afforded a new diglycoside which is gitoxigenin glucosido-digitoxoside and this was designated as glucogitoroside. Substance B-III' was examined by the same method and was shown to be a new cardiotonic pentaglycoside which has a structure of gitoxigenin cellobiosido-tridigitoxoside, and was named gitoxin cellobioside.
- 公益社団法人日本薬学会の論文
- 1959-03-20
著者
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岡野 淳二
Central Research Laboratory Daiichi Seiyaku Co. Ltd.
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三木 藤作
Exploratory Research Laboratories III, Daiichi Pharmaceutical Co., Ltd.,
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岡野 淳二
Research Laboratory, Daiichi Seiyaku Co., Ltd.
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傍士 和彦
Research Laboratory, Daiichi Seiyaku Co., Ltd.
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三木 藤作
Research Laboratory, Daiichi Seiyaku Co., Ltd.
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坂下 昭夫
Research Laboratory, Daiichi Seiyaku Co., Ltd.
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三木 藤作
Exploratory Research Laboratories Iii Daiichi Pharmaceutical Co. Ltd.
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傍士 和彦
第一製薬株式会社
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坂下 昭夫
Research Laboratory Daiichi Seiyaku Co. Ltd.
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