Medicinal Chemical Studies on Antiplasmin Drugs. II. Separation of Stereoisomers of 4-Aminomethylcyclohexanecarboxylic Acid and Assignment of Their Configuration

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概要

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• The stereoisomers of 4-aminomethylcyclohexanecarboxylic acid (I) and (II) were completely separated from their mixture, respectively, and it is proved that lowermelting isomer has the cis-configuration and higher-melting isomer whose antiplasmin activity is much potent has the trans-configuration.

• 公益社団法人日本薬学会の論文
• 1968-04-25

著者

• 清水 正夫

  Central Research Laboratory, Daiichi Seiyaku Co., Ltd.

• 岡野 淳二

  Central Research Laboratory Daiichi Seiyaku Co. Ltd.

• 内藤 武男

  Central Research Laboratory, Daiichi Seiyaku Co., Ltd.

• 三木 藤作

  Exploratory Research Laboratories III, Daiichi Pharmaceutical Co., Ltd.,

• 清水 正夫

  Central Research Laboratory Daiichi Seiyaku Co. Ltd.

• 内藤 武男

  Research Laboratories, Daiichi Seiyaku Co., Ltd.

• 門矢 静夫

  Central Research Laboratory, Daiichi Seiyaku Co., Ltd.

• 三木 藤作

  Central Research Laboratory, Daiichi Seiyaku Co., Ltd.

• 稲岡 万里

  Central Research Laboratory, Daiichi Seiyaku Co., Ltd.

• 諸井 黎明

  Central Research Laboratory, Daiichi Seiyaku Co., Ltd.

• 内藤 武男

  Research Laboratories Daiichi Seiyaku Co. Ltd.

• 門矢 静夫

  Research Institute Daiichi Seiyaku Co. Ltd.

• 三木 藤作

  Exploratory Research Laboratories Iii Daiichi Pharmaceutical Co. Ltd.

• 稲岡 万里

  Central Research Laboratory Daiichi Seiyaku Co. Ltd.

• 諸井 黎明

  Developmental Research Laboratories Daiichi Pharmaceutical Co. Ltd.

• Moroi R

  Developmental Research Laboratories Daiichi Pharmaceutical Co. Ltd.

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