Investigations on Pantothenic Acid and Its Related Compounds. V. Chemical Studies. (4). A Total Synthesis of Coenzyme A via Thiazoline Intermediate

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概要

• 論文の詳細を見る

• Synthesis of coenzyme A using thiazoline (Vb) as intermediate is described. D-Pantothenonitrile (I) was treated with adenosine 2', 3'-cyclic phosphate 5'-phosphoromorpholidate (IIb) in pyridine followed by ribonuclease T_2 to yield P^1-adenosine 3'-phosphate 5'-P^2-D-pantothenonitrile 4'-pyrophosphate (IVb). Condensation of IV b with cysteamine gave thiazoline (Vb), which was then hydrolyzed to afford coenzyme A.

• 公益社団法人日本薬学会の論文
• 1967-05-25

著者

• 清水 正夫

  Central Research Laboratory, Daiichi Seiyaku Co., Ltd.

• 細川 恭宏

  Research Laboratories, Daiichi Seiyaku Co., Ltd.

• 岡田 清三郎

  Research Laboratories, Daiichi Seiyaku Co., Ltd.

• 鈴木 忠生

  第一製薬総合研究所

• 安孫子 雍史

  第一製薬総合研究所

• 細川 恭宏

  Central Research Laboratory, Daiiohi Seiyaku Co., Ltd.

• 田川 博昭

  Central Research Laboratory, Daiichi Seiyaku Co., Ltd.

• 岡田 清三郎

  Central Research Laboratory, Daiichi Seiyaku Co., Ltd.

• 安孫子 雍史

  Central Research Laboratory, Daiichi Seiyaku Co., Ltd.

• 鈴木 忠生

  Central Research Laboratory, Daiichi Seiyaku Co., Ltd.

• 清水 正夫

  Central Research Laboratory Daiichi Seiyaku Co. Ltd.

• 長瀬 修

  Research Institute, Daiichi Seiyaku Co., Ltd.

• 長瀬 修

  Research Institute Daiichi Seiyaku Co. Ltd.

• 田川 博昭

  Research Laboratories Daiichi Seiyaku Co. Ltd.

• 長瀬 修

  Central Research Laboratory, Daiichi Seiyaku Co., Ltd.

• 細川 恭宏

  Research Laboratories Daiichi Seiyaku Co. Ltd.

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