Investigations on Steroids. IV. Syntheses of Androstano[2,3-c]-furazans and Related Compounds
スポンサーリンク
概要
- 論文の詳細を見る
Steroids with a furazan ring fused to the 2,3-positions were synthesized. 2,3-Dihydroxyiminoandrostanes (III) prepared from androstan-3-ones (I), via 2-hydroxyimino-3-ketones (IV), or 2,3-diketones (II), were cyclized directly to androstano[2,3-c]furazans (XVII) by means of alkali, succinic anhydride or thionyl chloride. Alternatively, 2,3-dihydroxyimino compounds (III) were treated with sodium hypochlorite or lead tetraacetate to afford the corresponding furazan N-oxides (furoxans)(XXI), which were deoxygenated to the furazans (XVII) by heating with triethyl phosphite. Similarly, androst-4-eno and androsta-4,6-dieno[2,3-c]furazans (XVII, XIX) were prepared. Syntheses of their derivatives were also described.
- 公益社団法人日本薬学会の論文
- 1965-12-25
著者
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清水 正夫
Central Research Laboratory, Daiichi Seiyaku Co., Ltd.
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太田 元吉
Central Research Laboratory, Daiichi Seiyaku Co., Ltd.
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上野 勝次郎
Central Research Laboratory, Daiichi Seiyaku Co., Ltd.
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竹越 敏夫
Central Research Laboratory, Daiichi Seiyaku Co., Ltd.
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竹越 敏夫
第一製薬
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清水 正夫
Central Research Laboratory Daiichi Seiyaku Co. Ltd.
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太田 元吉
第一製薬研究所
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上野 勝次郎
Research Institute, Daiichi Seiyaku Co., Ltd.
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上野 勝次郎
Research Institute Daiichi Seiyaku Co. Ltd.
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