Investigations on Steroids. XII. Metabolites of Furazabol (17β-Hydroxy-17α-methyl-5α-androstano [2,3-c] furazan) administered to Rats

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概要

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• Isolation and characterization of metabolites of furazabol (17β-hydroxy-17α-methyl-5α-androstano [2,3-c] furazan; IIa) following oral or subcutaneous administration of the compound to rats are described. From faeces were obtained the corresponding 18,17β-lactone (I), unchanged furazabol, the 16β-hydroxylated compound (III), the 18-hydroxy-lated compound (IV), the 17α-hydroxymethyl derivative (V), the 18-carboxylic acid (VII) and a compound assumed to be the 4β, 16ξ-dihydroxylated 18,17β-lactone (VI). In the bile the lactone (I) and probably the conjugated metabolites were present. Urinary metabolites were not characterized. The furazan ring of furazabol appeared to be stable in vivo. The metabolic significance of the isolated compounds is discussed.

• 公益社団法人日本薬学会の論文
• 1972-06-25

著者

• 竹越 敏夫

  第一製薬

• 立沢 晴男

  第一製薬株式会社中央研究所

• 太田 元吉

  第一製薬研究所

• 太田 元吉

  Research Laboratory Daiichi Seiyaku Co. Ltd.

• 竹越 敏夫

  Research Laboratories, Daiichi Seiyaku Co., Ltd.

• 立沢 晴男

  Research Laboratories, Daiichi Seiyaku Co., Ltd.

• 立沢 晴男

  第一製薬株式会社研究所

• 立沢 晴男

  Drug Metabolism Research Center Research Institute Daiichi Seiyaku Co. Ltd.

• 竹越 敏夫

  Research Institute Daiichi Seiyaku Co. Ltd.

関連論文

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