Protein Binding of Timiperone, 4'-Fluoro-4-[4-(2-thioxo-1-benzimi-dazolinyl) piperidino] butyrophenone, a Neuroleptic

概要

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The binding of timiperone to human plasma protein and human serum albumin in vitro was studied by using four different analytical procedures. After addition of timiperone to the plasma at concentrations of 10 and 100 ng/ml, more than 95% of timiperone was bound to the plasma protein. The finding that the binding ratio of the drug to human serum albumin was approximately 80% suggested that most of the timiperone in the plasma was bound to human albumin. More than 98% of protein-bound timiperone was extracted with trichloroacetic acid and 80% methanol solution. Thus, it was demonstrated that almost all the binding of the drug to human plasma protein is reversible.
社団法人日本薬学会の論文
1983-04-25