Studies on Hypolipidemic Agents. I. Synthesis of 1,3-Dioxolanes and 1,3-Dioxanes
スポンサーリンク
概要
- 論文の詳細を見る
2-Aryl-substituted 3a, 4,5,9b-tetrahydronaphtho [1,2-d]-1,3-dioxolanes (4), 5-phenyl-(6), 5-(1,2,3,4-tetrahydro-2-naphthyl)-(7) and 5-(2-naphthyl)-1,3-dioxanes (8) and 3-aryl-substituted 1H-naphtho [2,1-d] [1,3] dioxins (5) were synthesized. Among them, the 1,3-dioxanes (6-8) were each obtained as a mixture of the trans and cis isomers. Two stereoisomers of the 2-(3-pyridyl)-substituted derivatives (6c and 7c) and the trans isomers of the other 1,3-dioxanes (6-8) were isolated and their stereostructures are discussed. Most of the trans isomers of 6-8 showed potent hypolipidemic activity, while the cis isomers were inactive. The most active compound was the trans isomer of 7c.
- 公益社団法人日本薬学会の論文
- 1982-02-25
著者
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竹越 敏夫
第一製薬
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竹越 敏夫
Research Institute Daiichi Seiyaku Co. Ltd.
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江里 口明
Research Institute, Daiichi Seiyaku Co., Ltd.
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江里 口明
Research Institute Daiichi Seiyaku Co. Ltd.
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