Investigations on Steroids. XIII. Synthesis of the Compounds related to the Metabolites of Furazabol (17β-Hydroxy-17α-methyl-5α-androstano [2,3-c] furazan)
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The compounds required for the study of the metabolites of furazabol (17β-hydroxy-17α-methyl-5α-androstano [2,3-c] furazan ; Ia) were synthesized ; these are the labelled furazabol (Ib) with ^<14>C at 17α-methyl position, the 18-hydroxy derivative (II) of furazabol, the 18,17β-lactone (III), 18-oic acid (IVa), the 16β-hydroxy derivative (Va) and the 17α-hydroxymethyl derivative (VIa). Oxidation of the 18,17β-dihydroxy-17α-methyl compound (II) with chromic acid proved to give the corresponding 18,17β-lactone (III) and 18-oic acid (IVa).
- 公益社団法人日本薬学会の論文
- 1972-06-25
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- Investigations on Steroids. XIII. Synthesis of the Compounds related to the Metabolites of Furazabol (17β-Hydroxy-17α-methyl-5α-androstano [2,3-c] furazan)