Investigations on Pantothenic Acid and Its Related Compounds. XXIII. Chemical Studies. (10). Chemical Synthesis of Coenzyme A Analogs of a Modified Purine Base Moiety

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概要

• 論文の詳細を見る

• Two coenzyme A analogs having purine base different from adenine, such as inosino-(IV) and guano-coenzyme A (IX), have been synthesized by application of the method via the thiazoline intermediate in the same manner as the total synthesis of coenzyme A. Inosino-coenzyme A has been also obtained by deamination with nitrite from the disulfide from of coenzyme A. Synthesis of guano-coenzyme A has been more efficiently effected by a combination of the methods of Moffatt and Khorana, for the formation of pyrophosphate, and of Michelson, for 2', 3'-cyclic phosphate fission, than the thiazoline method.

• 公益社団法人日本薬学会の論文
• 1970-02-25

著者

• 清水 正夫

  Central Research Laboratory, Daiichi Seiyaku Co., Ltd.

• 長瀬 脩

  Research Institute Daiichi Seiyaku Co. Ltd.

• 細川 恭宏

  Research Laboratories, Daiichi Seiyaku Co., Ltd.

• 清水 正夫

  Research Laboratories, Daiichi Seiyaku Co., Ltd.

• 岡田 清三郎

  Research Laboratories, Daiichi Seiyaku Co., Ltd.

• 岡田 清三郎

  Central Research Laboratory, Daiichi Seiyaku Co., Ltd.

• 清水 正夫

  Central Research Laboratory Daiichi Seiyaku Co. Ltd.

• 岡田 清三郎

  Research Laboratories Daiichi Seiyaku Co. Ltd.

• 長瀬 脩

  Research Laboratories Daiichi Seiyaku Co. Ltd.

• 細川 恭宏

  Research Laboratories Daiichi Seiyaku Co. Ltd.

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