Investigations on Pantothenic Acid and Its Related Compounds. XIX. Chemical Studies. (9). Syntheses of 2'-Ketopantothenic Acid and 2', 2''-Diketopantethine

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概要

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• Wieland synthesized 2'-ketopantothenic acid [N-(4-hydroxy-3,3-dimethyl-2-oxobutyryl)-β-alanine] (Keto-PaA) (V) and reported its uneffectiveness as the growth factor for Streptobacterium plantarum 10 S (=Lactobacillus arabinosus). The keto compound (VI) corresponding to pantethine, 2', 2''-diketopantethine (Keto-PTSS), has not yet been known. It seems very interesting to examine the possibility of enzymatic conversion of these compounds to the corresponding active vitamins in mammalian body. This paper describes the synthesis of these keto compounds.

• 公益社団法人日本薬学会の論文
• 1969-02-25

著者

• 清水 正夫

  Central Research Laboratory, Daiichi Seiyaku Co., Ltd.

• 長瀬 脩

  Research Institute Daiichi Seiyaku Co. Ltd.

• 細川 恭宏

  Research Laboratories, Daiichi Seiyaku Co., Ltd.

• 長瀬 脩

  Central Research Laboratory, Daiiohi Seiyaku Co., Ltd.

• 細川 恭宏

  Central Research Laboratory, Daiiohi Seiyaku Co., Ltd.

• 清水 正夫

  Central Research Laboratory Daiichi Seiyaku Co. Ltd.

• 長瀬 脩

  Research Laboratories Daiichi Seiyaku Co. Ltd.

• 細川 恭宏

  Research Laboratories Daiichi Seiyaku Co. Ltd.

• 長瀬 脩

  Central Research Laboratory, Daiichi Seiyaku Co., Ltd.

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