Metabolism of Budralazine, a New Antihypertensive Agent. I. Identification of the Metabolites of Budralazine in Rats
スポンサーリンク
概要
- 論文の詳細を見る
The metabolism of budralazine in rats was investigated. Ten urinary metabolites were detected and identified after oral administration. Major metabolites were 3-methyl-s-triazolo [3,4-a] phthalazine and 1-(s-triazolo [3,4-a] phthalazine-3-carboxy)-β-D-glucopyranosiduronic acid. Comparison of the metabolic pattern obtained in spontaneously hypertensive rat and normotensive Wistar-strain rat was also discussed. But no significant difference was observed for the time course of biotransformation rate between them.
- 公益社団法人日本薬学会の論文
- 1976-11-25
著者
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真田 修一
School Of Pharmaceutical Sciences Showa University Hatanodai
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諸井 黎明
Research Institute, Daiichi Seiyaku Co., Ltd.
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秋元 健
Research Institute Daiichi Seiyaku Co. Ltd.
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小野 健司
Research Institute, Daiichi Seiyaku Co., Ltd.
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斎藤 董
Research Institute, Daiichi Seiyaku Co., Ltd.
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真田 修一
Research Institute, Daiichi Seiyaku Co., Ltd.
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小野 健司
Research Institute Daiichi Seiyaku Co. Ltd.
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斎藤 董
Research Institute Daiichi Seiyaku Co. Ltd.
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諸井 黎明
Developmental Research Laboratories Daiichi Pharmaceutical Co. Ltd.
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Moroi R
Developmental Research Laboratories Daiichi Pharmaceutical Co. Ltd.
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