Studies on Ketene and Its Derivatives. CVII. Photoreaction of Diketene with 6-Methyluracil
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概要
- 論文の詳細を見る
Photoreaction of diketene with 6-methyluracil gives rel-(1R, 6R, 8S)-1-methyl-3,5-dioxo-2,4-diazabicyclo [4. 2. 0] octane-8-spiro-2'-(oxetan)-4'-one (10a), rel-(1R, 6R, 8R)-1-methyl-3,5-dioxo-2,4-diazabicyclo [4. 2. 0] octane-8-spiro-2'-(oxetan)-4'-one (10b), rel-(1R, 6R, 7S)-1-methyl-3,5-dioxo-2,4-diazabicyclo [4. 2. 0] octane-7-spiro-2'-(oxetan)-4'-one (10c), and rel-(1R, 6R, 7R)-1-methyl-3,5-dioxo-2,4-diazabicyclo [4. 2. 0] octane-7-spiro-2'-(oxetan)-4'-one (10d). Heating of compounds 10a and 10b at their decomposition points results in decarboxylation to give rel-(1R, 6R)-1-methyl-8-methylene-3,5-dioxo-2,4-diazabicyclo [4. 2. 0] octane (11). Similarly, thermolysis of 10c and 10d affords rel-(1R, 6S)-1-methyl-7-methylene-3,5-dioxo-2,4-diazabicyclo [4. 2. 0] octane (12). Surtcture assignments of 10b and 10c by X-ray crystallographic analysis are described. The structures were solved by the direct method and refined to R values of 4.81% for 10b and 6.79% for 10c.
- 社団法人日本薬学会の論文
- 1982-02-25
著者
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千葉 卓男
Pharmaceutical Institute, Tohoku University
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千葉 卓男
Pharmaceutical Institute Tohoku University
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加藤 鉄三
東北大学 薬
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加藤 鉄三
Pharmaceutical Institute Tohoku University
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吉田 亜登美
Research Institute, Daiichi Seiyaku Co., Ltd.
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諸井 黎明
Research Institute, Daiichi Seiyaku Co., Ltd.
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高橋 仁
Pharmaceutical Institute, Tohoku University
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高橋 仁
Pharmaceutical Institute Tohoku University
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加藤 鉄三
Pharmaceutical Institute. Tohoku University
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諸井 黎明
Developmental Research Laboratories Daiichi Pharmaceutical Co. Ltd.
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吉田 亜登美
Research Institute Daiichi Seiyaku Co. Ltd.
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Moroi R
Developmental Research Laboratories Daiichi Pharmaceutical Co. Ltd.
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