Keteneおよびその誘導体の研究(第42報) : 1-Acetoacetylaziridine誘導体の環拡大反応
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概要
- 論文の詳細を見る
Reaction of diketene with ethylenimine (Ia), 2,2-dimethylaziridine (Ib), 2,2-diphenyl-3-methylaziridine (Ic), ethylaziridine-2-carboxylate (Id), aziridine-2-carboxamide (Ie), and 2-benzoyl-3-phenylaziridine (If) afford the corresponding 1-acetoacetylaziridines (II) in a good yield. Treatment of II with sodium iodide or conc. sulfuric acid results in their isomerization to 2-acetonyl-2-oxazoline derivatives (III or IV). Isomerization of IIb-e preferentially occurs only in one direction but treatment of IIf with sodium iodide produces IIIf and IVf at the same time. Warming of IIf in benzene results in its isomerization to 6-methyl-2-phenacyl-3,4-dihydro-2H-1,3-oxazin-4-one (XVII), while treatment of IIf with sodium ethoxide gives 3-acetyl-5-benzyl-4-phenylpyrrolenin-2-one (XIX).
- 社団法人日本薬学会の論文
- 1971-03-25
著者
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加藤 鉄三
東北大学 薬
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山本 豊
Pharmaceutical Institute, Tohoku University
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加藤 鉄三
東北大学医学部薬学科
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山本 豊
東北大学医学部薬学科
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佐藤 雅之
東北大学医学部薬学科
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加藤 鉄三
Pharmaceutical Institute. Tohoku University
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山本 豊
Pharmaceutical Institute Tohoku University
関連論文
- Photoaddition of 2-Quinolone and 2-Pyridone Derivatives to Diketene : On the Regioselectivity of the Photoaddition
- Studies on Ketene and Its Derivatives. XCV. Reaction of Diketene with Acyl Azides
- 1,3-Oxazine化学の最近の進歩 (ヘテロ環の化学-5-)
- Synthesis of Methylpyridine Derivatives. XXX. Reaction of Active Methylene Compounds with 6-Methyl-2-phenyl-4H-1,3-oxazin-4-one and 2-Ethoxy-2,6-dimethyl-2H-1,3-oxazin-4 (3H)-one to give 3-Acetylpyridone Derivatives
- Keteneおよびその誘導体の研究(第65報)KeteneとKetene Acetalとの反応
- Keteneおよびその誘導体の研究(第61報)第一アミンとChloroketene Diethylacetalとの反応
- Keteneおよびその誘導体の研究(第59報)5-Acetyl-2,6-dimethyl-4(3H)-pyrimidoneの閉環反応
- Studies on Ketene and Its Derivatives. LVII. Reaction of Diketene with β-Diketones
- Keteneおよびその誘導体の研究(第55報)第一アミンとKetene Acetalとの反応
- Studies on Ketene and Its Derivatives. LIV. Reaction of Diketene with Ketene Acetals
- ケテンおよびその誘導体の研究(第50報)脂肪族イミドエステルとジケテンとの反応
- Keteneおよびその誘導体の研究(第42報) : 1-Acetoacetylaziridine誘導体の環拡大反応
- Keteneおよびその誘導体の研究(第40報) : N-Ethylideneisopropylamine, N-Methylenecyclohexylamine, およびN-Methylene-tert-butylamineとDiketeneとの反応
- ケテンおよびその誘導体の研究(第37報) : Ketone Anilおよび関連化合物とジケテンとの反応
- Studies on Ketene and Its Derivatives. XVIII. Reaction of Diketene with Acridine.
- Studies on Ketene and Its Derivatives. XVII. Reaction of Diketene with Imidates.
- Keteneおよびその誘導体の研究(第16報) : Schiff BaseとDiketeneとの反応
- Studies on Ketene and Its Derivatives. XI. Reaction of Diketene with Phenanthridine
- Studies on Ketene and its Derivatives. X. Reaction of Diketene with Schiff Base
- Reaction of Ethyl 4-Bromoacetoacetate with Carbon Disulfide and Active Methylene Compounds
- Neighboring Group Participation of the N-Oxide Group in the Reaction of Methyl 1-Oxido-2-pyridyl Ketone Oxime with Tosyl Chloride
- Reaction of 4-Haloacetoacetate with Phenols in the Presence of Aluminum Chloride
- Studies on Ketene and Its Derivatives. CVII. Photoreaction of Diketene with 6-Methyluracil
- Studies on Ketene and Its Derivatives. CVI. Photoreaction of Diketene with N-Phenylmaleimide and Dimethyl-N-phenylmaleimide
- Studies on Ketene and Its Derivatives. CII. Reaction of Diketene with Cyanamide Derivatives
- アセトアセトアミド誘導体を用いたBiginelli反応
- ケテンおよびその誘導体の研究(第104報)3-アミノクロトンアミド誘導体とジケテンとの反応
- ジケテンのエキソメチレン二重結合の新しい付加反応
- ケテンおよびその誘導体の研究(第99報)ジケテンとイソキノリンとの反応(補遺)
- Studies on Ketene and Its Derivatives. XCVII. Photoreactions of Diketene with Maleic Anhydride and Dimethylmaleic Anhydride
- Isoquinolinium MethylidesとKetone類との反応
- Studies on Ketene and Its Derivatives. XCVI. Synthesis of Pyrido [2,1-b] benzoazoles
- Reaction of Ethyl Acetoacetate with Isoquinolinium and Pyridinium Ylides
- Synthesis of Methylpyridine Derivatives. XXXII. Reaction of Pyridine, Quinoline, and Isoquinoline with 4-Bromoacetoacetic Acid Derivatives and Synthesis of Indolizine Derivatives
- Reaction of Diazomethane with 2-Acetyl-5,5-diphenyl-2,4-pentadienoic Acid and Related Compounds
- Studies on Ketene and Its Derivatives. LXXXIV. Reaction of Diketene with Tetrazole Derivatives
- Studies on Ketene and Its Derivatives. LXXVII. Reaction of Diketene with Pyridineformimidates and Related Compounds to give 1,3-Oxazin-4-one Derivatives
- Studies on Ketene and Its Derivatives. LXXV. Reaction of Diketene with N-Benzylacetimidate and Lactim Ethers to give 1,6-Naphthyridine Derivatives
- Reaction of β-Aminocrotonamide with N-Acylated Amino Acid Esters to give 2-Acylaminoalkyl-6-methylpyrimidin-4 (3H)-ones and Their Ring Closure with Polyphosphoric Acid (PPA)
- Ring Transformation of 5-Oxo-4-oxaspiro [2.3] hexanes
- Studies on Ketene and Its Derivatives. XCIV. Reaction of Diketene with Diazoacetone and 2-Diazoesters
- ドクササコの有毒成分とその薬理作用
- Chemical Reactions of Bikaverin
- Studies on Ketene and Its Derivatives. LIII. Reaction of Diketene with Diazoacetophenone and Ethyl Diazoacetate
- Studies on Ketene and Its Derivatives. XLVIII. Reaction of Diketene with Hydroxylamine
- Studies on Ketene and Its Derivatives. XLVII. Reaction of 2-Aminopyridine with Diketene
- Studies on Ketene and Its Derivatives. XLVI. Mass Spectrometric Studies of 3-Acetyl-4-hydroxy-6-methyl-1-pyridyl-2-pyridones and N-Pyridyl-2,6-dimethyl-4-pyrone-3-carboxamides
- キノリン誘導体の塩素化反応
- Methylpyridine誘導体の合成(第29報)Methylpyridineおよび同族体のAryl化反応
- Studies on Ketene and Its Derivatives. LX. Reaction of Diketene with Quinoline 1-Oxide (Supplement)
- Synthesis of Methylpyridine Derivatives. XXVII. Synthesis of 1,3-Disubstituted-4-oxo-quinolizine and 2,4-Disubstituted-1-oxo-benzo [c] quinolizine Derivatives
- ケテンおよびその誘導体の研究(第58報)3-Aminocrotonamideとα, β-不飽和カルボン酸エステル類との反応
- Keteneおよびその誘導体の研究(第56報)Pyrrolidylidene誘導体とDiketeneによる5-Methyl-8-substituted-1,2,3,7-tetrahydroindolizine-7-oneの合成
- Methylpyridine誘導体の合成(第26報)3-Acylamido-4-chloro-2,6-lutidineの液体アンモニア中カリウムアミドによる閉環反応
- Studies on Ketene and Its Derivatives. XLIX. Reaction of Diketene with β-Ketoesters to give Ethyl Orsellinate, Divarate, Olivetol Carboxylate, and Sphaeropherol Carboxylate
- Keteneおよびその誘導体の研究(第45報) : 2-Alkyl-2-imidazolineとDiketeneとの反応
- 3-Amino-4-methyl-2-pentenamide, 2-Amino-1-cyclohexene-1-carboxamideおよび3-Amino-2,4-diphenyl-2-butenamideの合成ならびにそれらを用いた4(3H)-Pyrimidone誘導体の合成
- Synthesis of N-Acylacetoacetamide using 2,2,6-Trimethyl-1,3-dioxin-4-one
- Studies on Ketene and Its Derivatives. CV. Photoreaction of Diketene with sec-Alcohols
- Synthesis of Methylpyridine Derivatives. XXXIV. Condensation of Acetoacetamide with Ketones to form Pyridone Derivatives
- Studies on Ketene and Its Derivatives. XCII. Reaction of Diketene with Benzaldehyde, Cinnamaldehyde, and β-Phenylcinnamaldehyde
- Studies on Ketene and Its Derivatives. LXXXVII. Photoreaction of Diketene with 3-Acetoxy-5,5-dimethyl-2-cyclohexenone
- Studies on Ketene and Its Derivatives. LXIX. Reaction of Diketene with Hydrazobenzenes
- Studies on Ketene and Its Derivatives. LXVII. Photoreaction of Benzophenone and Benzaldehyde with Diketene
- ケテンおよびその誘導体の研究(第52報)ジケテンとα(β)-アミノニトリルとの反応
- ケテンおよびその誘導体の研究(第51報))α-アミノ酸アミドとジケテンとの反応
- Studies on Ketene and Its Derivatives. XLI. Reaction of α-Aminoketone with Diketene
- アセトンジカルボン酸と無水酢酸との反応(第2報)
- Keteneおよびその誘導体の研究(第34報) : Diketeneとウレタンおよび酸アミドとの反応
- Keteneおよびその誘導体の研究(第30報) : Diketeneとアンモニアおよび脂肪族アミンとの反応
- Keteneおよびその誘導体の研究(第23報) : Diketeneとα-アミノ酸との反応
- Keteneおよびその誘導体の研究(第22報) : Diketeneとアニリン誘導体との反応
- Studies on Ketene and Its Derivatives. XXVIII. Reaction of β-Aminocrotonamide with Ketene and Diketene
- ケテンおよびその誘導体の研究(第36報) : Acetoacetamideおよびβ-Aminocrotonamideとアルデヒドとの反応
- Keteneおよびその誘導体の研究(第14報) : Diethyl2,5-dihydroxyterephthalateの合成
- Keteneおよびその誘導体の研究(第15報) : Quinoline-Diketene付加体とAmmoniaとの反応成績体
- ジケテンのエキソメチレンニ重結合の新しい付加反応
- メチルピリジン誘導体の合成(第24報) : Methyl Pyridyl Ketone Oximeおよびそれらの1-OxideのBeckmann転位
- メチルピリジン誘導体の合成(第25報) : α-置換-2-pyridineacetonitrile誘導体の合成
- Synthesis of 1-Substituted-1,2,5,6-tetrahydro-4H-pyrrolo (3,2,1-ij) quinolin-2-one
- Studies on Ketene and Its Derivatives. XXXIX. Reaction of Diketene with Semicarbazone
- Studies on Ketene and Its Derivatives. XXXVIII. Reaction of Diketene with Phenylhydrazones to give 4-Acetyl-2-phenylpyrazolidin-3-ones
- Keteneおよびその誘導体の研究(第44報) : β-AminocinnamonitrileとEthyl Acetoacetateとから得られるピリドン誘導体の構造について
- ケテンおよびその誘導体の研究(第43報) : Primary EnamineとKeteneまたはDiketeneとの反応
- ケテンおよびその誘導体の研究(第20報) : Diketeneと2-Pyridylacetonitrileとの反応
- Studies on the Synthesis of Indole Related Compounds. II. Diels-Alder Reaction of Phenacylidene Indolinone
- Indole関連化合物の合成研究(第1報) : 3-Acetyl-2-indolinone
- メチルピリミジン誘導体と亜硝酸イソアミルとの反応
- メチルピリミジン誘導体のVilsmeier反応
- ケテンおよびその誘導体の研究(第33報) : Ethyl 3-Aminocrotonateのアセチル化反応
- Keteneおよびその誘導体の研究(第27報) : β-Aminocrotonamideのアシル化および閉環反応
- Keteneおよびその誘導体の研究(第25報) : 3-Acetyl-4-hydroxy-6-methyl-1H-2-pyridone OximeおよびDehydroacetic Acid Oximeの閉環反応
- ケテンおよびその誘導体の研究(第35報) : β-Aminocrotonamideとカルボン酸エステルとによる2-置換-6-メチルピリミドンの合成法
- ピリミジン誘導体の N-オキシド化反応
- ケテンおよびその誘導体の研究(第19報) : 2-アルキル(アリル)置換-6-メチル-4-ピリミドンの新合成法
- Keteneおよびその誘導体の研究(第29報) : Quinolizine誘導体の合成
- ジケテン
- Keteneおよびその誘導体の研究(第24報) : DiketeneとKetimineとの反応
- メチルピリジン誘導体の合成(第23報) : 2,6-Lutidine誘導体のクロル化反応
- Methylpyrimidine誘導体のクロル化反応