Reaction of β-Aminocrotonamide with N-Acylated Amino Acid Esters to give 2-Acylaminoalkyl-6-methylpyrimidin-4 (3H)-ones and Their Ring Closure with Polyphosphoric Acid (PPA)

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概要

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• Reaction of β-aminocrotonamide with N-acylated amino acid esters in the presence of sodium methoxide gave 2-acylaminoalkyl-6-methylpyrimidin-4 (3H)-ones, some of which, on treatment with polyphosphoric acid (PPA), were transformed into imidazo [1,5-a] pyrimidines and imidazo [4,5-b] pyridines.

• 公益社団法人日本薬学会の論文
• 1983-07-25

著者

• 加藤 鉄三

  東北大学 薬

• 加藤 鉄三

  Pharmaceutical Institute Tohoku University

• 片桐 信弥

  Pharmaceutical Institute, Tohoku University

• 片桐 信弥

  Health Sci. Univ. Hokkaido Hokkaido Jpn

• 片桐 信弥

  Pharmaceutical Institute Tohoku University

• 厚海 修吾

  Pharmaceutical Institute, Tohoku University

• 腰原 朱美

  Pharmaceutical Institute, Tohoku University

• 加藤 鉄三

  Pharmaceutical Institute. Tohoku University

• 厚海 修吾

  Structural Biology & Chemistry New Drug Discovery Research Laboratories Tsukuba Research Institu

• 腰原 朱美

  Pharmaceutical Institute Tohoku University

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