Diketeneより誘導された化合物, ならびに関連化合物の抗腫瘍性スクリーニング
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概要
- 論文の詳細を見る
Various derivatives containing acetoacetamide, β-aminocrotonamide, pyrimidine, pyridine, dihydroxybenzoic acid, quinoline, pyridone, 2-pyrone and 2-pyrrolidone were prepared mainly from diketene. Their anti-tumor activities were examined by use of ascitic or solid type of Ehrlich carcinoma, and among them eleven compounds were found to have some anti-tumor effects on this solid tumor. These compounds were derivatives of pyrimidine (No. 30), pyridine (No. 41,42,54,55,56,57 and 63), 2-pyrone (No. 124 and 125) and pyridopyrimidine (No. 137). No correlation was found between anti-tumor activity and these derivatives. No other substances in Table I-XII ; were effective.
- 社団法人日本薬学会の論文
- 1977-06-25
著者
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水野 伝一
東京大学薬学部
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水野 伝一
Faculty Of Pharmaceutical Sciences Teikyo University
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水野 伝一
帝京大学
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佐々木 俊樹
東北大学薬学部
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和賀井 昭博
Pharmaceutical Institute Tohoku University
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加藤 鉄三
Pharmaceutical Institute, Tohoku University
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加藤 鉄三
Pharmaceutical Institute Tohoku University
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木村 仁
Pharmaceutical Institute, Tohoku University
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木村 仁
Pharmaceutical Institute Tohoku University
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