Reaction of Ethyl 4-Halo-3-oxobutanoate with Diethyl Malonate, Methyl Cyanoacetate, and Malononitrile
スポンサーリンク
概要
- 論文の詳細を見る
Ethyl 4-bromo (and chloro)-3-oxobutanoate (1 and 2) reacts with diethyl malonate in the presence of sodium hydride to give diethyl 5-ethoxycarbonyl-3-oxohexanedioate (3) and diethyl 5-carboxy-3-oxohexanedioate (4). Similarly, reaction of the haloester (1,2) with methyl cyanoacetate gives 1-ethyl methyl 5-cyano-3-oxohexanedioate (6) and 1-ethyl hydrogen 5-cyano-3-oxohexanedioate (7). On the other hand, 1 reacts with malononitrile in the presence of triethylamine to give ethyl 5-amino-4-cyanofuran-2-acetate (8) and ethyl 3-amino-2,4,4-tricyano-2-cyclopenten-1-ylideneacetate (9).
- 社団法人日本薬学会の論文
- 1978-12-25
著者
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加藤 鉄三
Pharmaceutical Institute, Tohoku University
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加藤 鉄三
Pharmaceutical Institute Tohoku University
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木村 仁
Pharmaceutical Institute, Tohoku University
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丹治 健一
Pharmaceutical Institute, Tohoku University
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丹治 健一
School Of Food & Nutritional Sciences University Of Shizuoka
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木村 仁
Pharmaceutical Institute Tohoku University
関連論文
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- Ring Transformation of Fused Pyridazines. III. 1-Substituted Phthalazines with Ynamines
- New N-N Bond Cleavage of Fused Chloropyridazines with Ynamines
- N-N BOND CLEAVAGE OF 1-CHLOROPHTHALAZINE BY THE REACTION WITH YNAMINES
- Condensed Pyridazines. VIII. Reaction of Diazolopyridazines with Ynamine. Formation of Ben-zodiazoles and Diazolodiazocines
- Studies on Pyrazolo[3,4-d]pyrimidne Derivatives. XVII. : Reactions of 5-Benzoyl-4,5-dihydro-6-methyl-1-phenyl-1H-pyrazolo[3,4-d]pyrimidine-4-carbonitrile : The 6-Methylpyrazolopyrimidine Reissert Compound
- Purines. VIII. : Reactions of 1-Benzoyl-1,6-dihydro-9-phenyl-9H-purine-6-carbonitrile (9-Phenylpurine Reissert Compound) with Acid, Bases, and Electrophiles
- Condensed Pyridazines. VII. : Reaction of 7-(Methylsulfonyl)-1-phenyl-1H-imidazo[4,5-d]pyridazine with Nucleophiles
- General Pharmacological Actions of N-Acetoacetyl-3-hydroxytyrosine
- Studies on Ketene and Its Derivatives. XCV. Reaction of Diketene with Acyl Azides
- Synthesis of dl-Dehydroiridodiol
- Studies on Ketene and Its Derivatives. CI. Reaction of Diketene with 4-Amino-methylpyridine 1-Oxides
- Synthesis of Dihydrojasmone and cis-Jasmone
- Reaction of Ethyl 4-Halo-3-oxobutanoate with Diethyl Malonate, Methyl Cyanoacetate, and Malononitrile
- Studies on Ketene and Its Derivatives. LXXXV. Reactions of 4-Bromo-3-hydroxybutanoate and Its Acyl Derivatives
- Synthesis of Methylpyridine Derivatives. XXX. Reaction of Active Methylene Compounds with 6-Methyl-2-phenyl-4H-1,3-oxazin-4-one and 2-Ethoxy-2,6-dimethyl-2H-1,3-oxazin-4 (3H)-one to give 3-Acetylpyridone Derivatives
- Studies on Ketene and Its Derivatives. LVII. Reaction of Diketene with β-Diketones
- Studies on Ketene and Its Derivatives. LIV. Reaction of Diketene with Ketene Acetals
- Studies on Ketene and Its Derivatives. XVIII. Reaction of Diketene with Acridine.
- Studies on Ketene and Its Derivatives. XVII. Reaction of Diketene with Imidates.
- Studies on Ketene and Its Derivatives. XI. Reaction of Diketene with Phenanthridine
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- Triazole[4,5-d]pyrimidines. IX. Reactions of 5-Chloro- and 5-(Methylsulfonyl)-3-phenyl-3H-1,2,3-triazolo[4,5-d]pyrimidines with C-Nuclephiles
- Purines. VII. : Hydration and Methoxylation of Alkynyl-9H-purines
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- Quinoxalines. XXII. Aryl Migration of 2-Aroylquinoxalines to 2-Arylquinoxalines
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- Studies on Pyrimidine Derivatives. XXVII. Synthesis of 2- and 4-Pyrimidinyl Ketones by Means of the Hydration of Alkynylpyrimidines
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- Reaction of 4-Haloacetoacetate with Phenols in the Presence of Aluminum Chloride
- Studies on Ketene and Its Derivatives. CVII. Photoreaction of Diketene with 6-Methyluracil
- Studies on Ketene and Its Derivatives. CVI. Photoreaction of Diketene with N-Phenylmaleimide and Dimethyl-N-phenylmaleimide
- Studies on Ketene and Its Derivatives. CII. Reaction of Diketene with Cyanamide Derivatives
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- Reaction of Diazomethane with 2-Acetyl-5,5-diphenyl-2,4-pentadienoic Acid and Related Compounds
- Studies on Ketene and Its Derivatives. LXXXIV. Reaction of Diketene with Tetrazole Derivatives
- Studies on Ketene and Its Derivatives. LXXVII. Reaction of Diketene with Pyridineformimidates and Related Compounds to give 1,3-Oxazin-4-one Derivatives
- Studies on Ketene and Its Derivatives. LXXV. Reaction of Diketene with N-Benzylacetimidate and Lactim Ethers to give 1,6-Naphthyridine Derivatives
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- Studies on Ketene and Its Derivatives. XLVII. Reaction of 2-Aminopyridine with Diketene
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- Studies on Organometallic Compounds. I. Insertion Reaction of Diketene into N-Si Bond of Silylated Amides
- Studies on Ketene and Its Derivatives. LX. Reaction of Diketene with Quinoline 1-Oxide (Supplement)
- Synthesis of Methylpyridine Derivatives. XXVII. Synthesis of 1,3-Disubstituted-4-oxo-quinolizine and 2,4-Disubstituted-1-oxo-benzo [c] quinolizine Derivatives
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- Synthesis of N-Acylacetoacetamide using 2,2,6-Trimethyl-1,3-dioxin-4-one
- Studies on Ketene and Its Derivatives. CV. Photoreaction of Diketene with sec-Alcohols
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- Studies on Ketene and Its Derivatives. XCII. Reaction of Diketene with Benzaldehyde, Cinnamaldehyde, and β-Phenylcinnamaldehyde
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