Studies on Ketene and Its Derivatives. LXXVII. Reaction of Diketene with Pyridineformimidates and Related Compounds to give 1,3-Oxazin-4-one Derivatives
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概要
- 論文の詳細を見る
Reaction of diketene with ethyl pyridineformimidates (Ia-e) resulted in the formation of 6-methyl-2-pyridyl-4H-1,3-oxazin-4-one (IVa-c) and 2-ethoxy-6-methyl-2-pyridyl-2H-1,3-oxazin-4 (3H)-one (IIIb, c). Similar reaction with ethyl 2-quinolineformimidate (Id) and methyl 2-pyridineacetimidate (Ie) gave 6-methyl-2-(2-quinolyl)-4H-1,3-oxazine-4-one (IVd) and 2-methoxy-6-methyl-2-(2-pyridylmethyl)-2H-1,3-oxazin-4 (3H)-one (IIIe), respectively. The products obtained were treated with ammonia to give 6-methyl-2-substituted-4 (3H)-pyrimidone (Va-e). Hydrolysis of IIIe gave 6-hydroxy-4-methyl-3 (or 5)-(2-pyridyl)-2 (1H)-pyridone (VIII).
- 社団法人日本薬学会の論文
- 1976-02-25
著者
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加藤 鉄三
東北大学 薬
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加藤 鉄三
Pharmaceutical Institute Tohoku University
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近藤 正嗣
Pharmaceutical Institute, Tohoku University
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近藤 正嗣
Pharmaceutical Institute Tohoku University
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