Studies on Ketene and Its Derivatives. CVI. Photoreaction of Diketene with N-Phenylmaleimide and Dimethyl-N-phenylmaleimide
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概要
- 論文の詳細を見る
Photoreaction of diketene with N-phenylmaleimide (2) and its dimethyl derivative 3 gave rel-(4R, 5S, 6S)- and rel-(4R, 5R, 6R)-2-oxo-1-oxaspiro [3. 3] heptane-5,6-dicarboximides (4a and 4b) and their dimethyl derivatives 5a and 5b, respectively. Alcoholysis of compounds 4a and 4b with alcoholic hydrogen chloride gave 5-alkoxycarbonyl-4-oxo-N-phenyl-1,2-pentanedicarboximides 7 and 8,which were transformed to the corresponding 5-alkoxycarbonyl-3-oxoheptanedioates 9 and 10 by further alcoholysis. Compounds 4a and 4b were hydrolyzed with 10% hydrochloric acid to give 3-carboxy-5-oxohexanoic acid (11). Thermolysis of compounds 4a and 4b gave 3-methylenecyclobutane-1,2-dicarboximide (12).
- 社団法人日本薬学会の論文
- 1981-12-25
著者
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千葉 卓男
Pharmaceutical Institute, Tohoku University
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千葉 卓男
Pharmaceutical Institute Tohoku University
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加藤 鉄三
東北大学 薬
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加藤 鉄三
Pharmaceutical Institute Tohoku University
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土屋 享
Pharmaceutical Institute, Tohoku University
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加藤 鉄三
Pharmaceutical Institute. Tohoku University
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土屋 享
Pharmaceutical Institute Tohoku University
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