A SIMPLE METHOD FOR SYNTHESIZING 7-OXO-4-THIA-1-AZABICYCLO [3. 2. 0]-HEPTANE AND ITS 6-METHYL DERIVATIVES FROM ETHYL CYANOACETATE

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概要

• 論文の詳細を見る

• Ethyl cyanoacetate (1a) or its methyl derivatives (1b and 1c) were treated with HCl/EtOH to give the corresponding imidates (2a-2c). Treatment of the latter compounds with cysteamine gave ethyl 2-thiazoline-2-acetate (3a-3c), which by reduction with sodium cyanoborohydride in HCl/MeOH gave the corresponding thiazolidines (4a-4c). Hydrolysis followed by β-lactam formation through the use of Mukaiyama-Ohno's reagent afforded 7-oxo-4-thia-1-azabicyclo [3. 2. 0] heptane (6a) and its methylated derivatives (6b and 6c).

• 公益社団法人日本薬学会の論文
• 1985-07-25

著者

• 高橋 工

  Pharmaceutical Institute Tohoku University

• 金子 主税

  Faculty Of Pharmaceutical Sciences Kanazawa University

• 金子 主税

  Pharmaceutical Institute Medical Faculty University Of Tokyo

• 千葉 卓男

  Pharmaceutical Institute, Tohoku University

• 千葉 卓男

  Pharmaceutical Institute Tohoku University

• Sakaki Junichi

  Pharmaceutical Institute, Tohoku University

• Sakaki J

  Tohoku Univ. Sendai Jpn

• 金子 主税

  Pharmaceutical Institute Tohoku University

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