Polarisation der Heterozyklischen Ringe mit aromatischem Charakter. CXXXVII. Bemerkung zur Nitrierung des Pyridin-1-oxydes mittels Acylnitrates und uber 3,5-Dinitropyridin-1-oxyd.

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概要

• 論文の詳細を見る

• Pyridin-1-oxyd ergab bei der Nitrierung mit einer aquivalenten Menge von p-Nitrobenzoylchlorid und Silbernitrat in Chloroform-Losung das 3-Nitroderivat und 3,5-Dinitroderivat mit der Ausbeute von je ca. 9〜10% unter 40〜50% Regenerierung des Ausgangsmaterials. 3,5-Dinitropyridin-1-oxyd ist sehr empfindlich gegen Alkalien. Es ist in NaHCO_3-bzw. K_2CO_3-Losung mit roter Farbe und in NaOH-Losung mit gelber Farbe loslich und verandert sich in der Losung langsam. Der Farbumschlag in der Karbonat- und Lauge-Losung ist reversibel. 3-Nitropyridin-1-oxyd bzw. 3,5-Dinitropyidin-1-oxyd ergab beim Erhitzen mit Phosphoroxychlorid oder Phosphorpentachlorid das entsprechende 2-Chlorpyridin-Derivat.

• 公益社団法人日本薬学会の論文
• 1960-01-25

著者

• 金子 主税

  Faculty Of Pharmaceutical Sciences Kanazawa University

• 金子 主税

  Pharmaceutical Institute Medical Faculty University Of Tokyo

• 落合 英二

  Pharmazeutische Fakultat, Universitat Tokio

• 落合 英二

  ITSUU Laboratory

• 落合 英二

  Pharm. Institut D. Mediz. Fakultat D. Universitat Tokyo

• 落合 英二

  Faculty Of Pharmaceutical Sciences University Of Tokyo And Research Laboratory Shionogi & Co. Lt

• 金子 主税

  Pharmaceutical Institute Tohoku University

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