Synthesis of 1α, 24 (R)- and 1α, 24 (S)-Dihydroxycholesterol from Cholic Acid Derivatives
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概要
- 論文の詳細を見る
From 5α-cholestane-3α, 24 (R)- or -3α, 24 (S)-diol (2a and 2b) obtained from lithocholic acid in the previous work, both 24-epimers of 1α, 24-dihydroxycholesterol (6a and 6b) were synthesized. Thus, syntheses of these compounds were accomplished by dehydrogenation of the diols with dichlorodicyanobenzoquinone followed by the 1α-hydroxylation of the resulted 1,4-dien-3-ones (3a and 3b) by the three-step procedure originally uncovered by one of the present authors (C. K.). The last step in the above transformation, the modified procedure reported recently by Ikekawa's group : oxymercuration-demercuration, was used. An alternative preparation of 1α, 24ξ-dihydroxycholesterol (6) either from lithocholic acid or from hyodeoxycholic acid was also described.
- 公益社団法人日本薬学会の論文
- 1978-08-25
著者
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金子 主税
Faculty Of Pharmaceutical Sciences Kanazawa University
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新藤 実
Research Laboratories, Chugai Pharmaceutical Co., Ltd.
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新藤 実
New Drug Research Laboratories Chugai Pharmaceutical Co. Ltd.
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松永 功
New Drug Research Laboratories Chugai Pharmaceutical Co. Ltd.
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越智 清成
Exploratory Research Laboratories, Chugai Pharmaceutical Co., Ltd.,
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金子 主税
Pharmaceutical Institute Tohoku University
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越智 清成
Exploratory Research Laboratories Chugai Pharmaceutical Co. Ltd.
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松永 功
New Drug Research Laboratories, Chugai Pharmaceutical Co., Ltd.,
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